ArticleThe Journal of clinical investigation1992
Major histocompatibility complex haplotypes and complement C4 alleles in systemic lupus erythematosus. Results of a multicenter study.
Article in The Journal of clinical investigation, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 146 citations in OpenAlex.
- Characterization of B-cell lines from SLE patients and their relatives.Rheumatology international · 1995Trial
- Variants in TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3 interact to confer risk of systemic lupus erythematosus in Chinese population.Rheumatology international · 2014Article
- Identification of altered plasma proteins by proteomic study in valvular heart diseases and the potential clinical significance.PloS one · 2013Article
- Role of MHC-linked susceptibility genes in the pathogenesis of human and murine lupus.Clinical & developmental immunology · 2012Review
- MHC region and risk of systemic lupus erythematosus in African American women.Human genetics · 2011Article
- Spontaneous lupus-like syndrome in HLA-DQ2 transgenic mice with a mixed genetic background.Lupus · 2010Article
- Recent advances in the genetics of systemic lupus erythematosus.Expert review of clinical immunology · 2010Review
- Genetic studies of systemic lupus erythematosus in Asia: where are we now?Genes and immunity · 2009Article
- Copy number variation in the human genome and its implication in autoimmunity.Clinical and experimental immunology · 2009Review
- Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population.Journal of human genetics · 2008Article
- Identification of two independent risk factors for lupus within the MHC in United Kingdom families.PLoS genetics · 2007Article
- Receptor-ligand analyses define minimal killer cell Ig-like receptor (KIR) in humans.Immunogenetics · 2007Article
- Current status of lupus genetics.Arthritis research & therapy · 2007Review
- MHC class II, tumour necrosis factor alpha, and lymphotoxin alpha gene haplotype associations with serological subsets of systemic lupus erythematosus.Annals of the rheumatic diseases · 2006Article
- Definition of risk factors for death, end stage renal disease, and thromboembolic events in a monocentric cohort of 338 patients with systemic lupus erythematosus.Annals of the rheumatic diseases · 2002Article
- The genetics of systemic lupus erythematosus: putting the pieces together.Genes and immunity · 2002Review
- Fcgamma receptor IIa, IIIa, and IIIb polymorphisms in German patients with systemic lupus erythematosus: association with clinical symptoms.Annals of the rheumatic diseases · 2002Article
- Six microsatellite markers on the short arm of chromosome 6 in relation to HLA-DR3 and TNF-308A in systemic lupus erythematosus.Genes and immunity · 2001Article
- Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test.Genes and immunity · 2001Article
- Lack of evidence of a specific role for C4A gene deficiency in determining disease susceptibility among C4-deficient patients with systemic lupus erythematosus (SLE).Clinical and experimental immunology · 2001Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a multicenter study more than 300 central European systemic lupus erythematosus (SLE) patients were examined for HLA-B, HLA-DR, and complement C4 phenotypes. For 174 SLE patients MHC haplotypes were determined by family segregation analysis, and for 155 patients C4 gene deletions were determined by TaqI restriction fragment length polymorphism. Two haplotypes, B8-C4AQ0-C4B1-DR3 and B7-C4A3-C4B1-DR2, were identified as risk factors for SLE. These findings were confirmed by applying the haplotype frequency difference (HFD) method, which uses nontransmitted haplotypes from the family study as internal controls. Furthermore, only HLA-DR2, but not DR3, B7, or B8, was significantly increased in SLE patients independently of the two risk haplotypes. C4A gene deletions, but not silent C4AQ0 alleles, were increased in SLE patients and neither C4BQ0 alleles nor C4B gene deletions were increased. The observed frequencies of homozygosity and heterozygosity for the two haplotypes and the frequencies of homozygotes for C4AQ0 and C4A deletions did not differ from the expected values, indicating that the risk for SLE is conveyed by single allele effects. In conclusion, there are two MHC-linked susceptibility factors for Caucasian SLE patients carried by the haplotypes B7-DR2 and B8-DR3. The results argue against C4Q0 alleles being the decisive factors increasing susceptibility to SLE.
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