ArticleThe Journal of cell biology1992
Glycosyl phosphatidylinositol--anchored T-cadherin mediates calcium-dependent, homophilic cell adhesion.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 160 citations in OpenAlex.
- Cadherins orchestrate specific patterns of perisomatic inhibition onto distinct pyramidal cell populations.Nature communications · 2025Article
- Decoding the enigmatic role of T-cadherin in tumor angiogenesis.Frontiers in immunology · 2025Review
- Cadherin-13 Maintains Retinotectal Synapses via Transneuronal Interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The Missing Protein: Is T-Cadherin a Previously Unknown GPI-Anchored Receptor on Platelets?Membranes · 2021Article
- Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse.Frontiers in molecular neuroscience · 2021Article
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Conditional deletion of Cadherin 13 perturbs Golgi cells and disrupts social and cognitive behaviors.Genes, brain, and behavior · 2018Article
- The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction.Neural plasticity · 2018Review
- Adiponectin as a Potential Therapeutic Target for Prostate Cancer.Current pharmaceutical design · 2017Review
- Cadherin 13: humanMolecular medicine (Cambridge, Mass.) · 2016Article
- Positive feedback regulation between adiponectin and T-cadherin impacts adiponectin levels in tissue and plasma of male mice.Endocrinology · 2015Article
- Sorting out a promiscuous superfamily: towards cadherin connectomics.Trends in cell biology · 2014Review
- Adiponectin signaling in the liver.Reviews in endocrine & metabolic disorders · 2014Review
- Multifaceted roles of adiponectin in cancer.Best practice & research. Clinical endocrinology & metabolism · 2014Review
- Genome-wide association analysis of avian resistance to Campylobacter jejuni colonization identifies risk locus spanning the CDH13 gene.G3 (Bethesda, Md.) · 2013Article
- Effects of T-cadherin expression on B16F10 melanoma cells.Oncology letters · 2013Article
- Functional properties of rare missense variants of human CDH13 found in adult attention deficit/hyperactivity disorder (ADHD) patients.PloS one · 2013Article
- Receptors of garlic (Allium sativum) lectins and their role in insecticidal action.The protein journal · 2012Review
- T-cadherin is critical for adiponectin-mediated cardioprotection in mice.The Journal of clinical investigation · 2010Article
- T-cadherin structures reveal a novel adhesive binding mechanism.Nature structural & molecular biology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cadherins are a family of cell adhesion molecules that exhibit calcium-dependent, homophilic binding. Their function depends on both an HisAlaVal sequence in the first extracellular domain, EC1, and the interaction of a conserved cytoplasmic region with intracellular proteins. T-cadherin is an unusual member of the cadherin family that lacks the HisAlaVal motif and is anchored to the membrane through a glycosyl phosphatidylinositol moiety (Ranscht, B., and M. T. Dours-Zimmermann. 1991. Neuron. 7:391-402). To assay the function of T-cadherin in cell adhesion, we have transfected T-cadherin cDNA into CHO cells. Two proteins, mature T-cadherin and the uncleaved T-cadherin precursor, were produced from T-cadherin cDNA. The T-cadherin proteins differed from classical cadherins in several aspects. First, the uncleaved T-cadherin precursor was expressed, together with mature T-cadherin, on the surface of the transfected cells. Second, in the absence of calcium, T-cadherin was more resistant to proteolytic cleavage than other cadherins. Lastly, in contrast to classical cadherins, T-cadherin was not concentrated into cell-cell contacts between transfected cells in monolayer cultures. In cellular aggregation assays, T-cadherin induced calcium-dependent, homophilic adhesion which was abolished by treatment of T-cadherin-transfected cells with phosphatidylinositol-specific phospholipase C. These results demonstrate that T-cadherin is a functional cadherin that differs in several properties from classical cadherins. The function of T-cadherin in homophilic cell recognition implies that the mechanism of T-cadherin-induced adhesion is distinct from that of classical cadherins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.