ArticleThe Journal of cell biology1992
Suppression of tumorigenicity in transformed cells after transfection with vinculin cDNA.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 227 citations in OpenAlex.
- Spatial relationships between vinculin tension and actin at cell adhesions define cell colony positioning and identity.Biophysical journal · 2026Article
- Elevated Serum Vinculin in Patients with HBV/HCV-Associated Liver Cirrhosis and Hepatocellular Carcinoma: A Pilot Study.Biologics : targets & therapy · 2023Article
- A Protein Composite Neural Scaffold Modulates Astrocyte Migration and Transcriptome Profile.Macromolecular bioscience · 2022Article
- Adhesion strength and anti-tumor agents regulate vinculin of breast cancer cells.Frontiers in oncology · 2022Article
- Cervical cancer-derived exosomal miR-663b promotes angiogenesis by inhibiting vinculin expression in vascular endothelial cells.Cancer cell international · 2021Article
- Inside-out regulation of E-cadherin conformation and adhesion.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- MiR-200a Regulates Nasopharyngeal Carcinoma Cell Migration and Invasion by Targeting MYH10.Journal of Cancer · 2020Article
- miR-30b-5p acts as a tumor suppressor microRNA in esophageal squamous cell carcinoma.Journal of thoracic disease · 2019Article
- p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis.Nature communications · 2018Article
- Differential Modulation of Transcription Factors and Cytoskeletal Proteins in Prostate Carcinoma Cells by a Bacterial Lactone.BioMed research international · 2018Article
- Loss of ERα induces amoeboid-like migration of breast cancer cells by downregulating vinculin.Nature communications · 2017Article
- Human fibroblasts display a differential focal adhesion phenotype relative to chimpanzee.Evolution, medicine, and public health · 2016Article
- Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness.Biophysical journal · 2015Article
- Loss of vinculin and membrane-bound β-catenin promotes metastasis and predicts poor prognosis in colorectal cancer.Molecular cancer · 2014Article
- Mono-(2-ethylhexyl) phthalate (MEHP) promotes invasion and migration of human testicular embryonal carcinoma cells.Biology of reproduction · 2012Article
- Rac-dependent doubling of HeLa cell area and impairment of cell migration and cell cycle by compounds from Iris germanica.Protoplasma · 2011Article
- Aniline-induced nitrosative stress in rat spleen: proteomic identification of nitrated proteins.Toxicology and applied pharmacology · 2011Article
- New insights into vinculin function and regulation.International review of cell and molecular biology · 2011Review
- The vinculin-DeltaIn20/21 mouse: characteristics of a constitutive, actin-binding deficient splice variant of vinculin.PloS one · 2010Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transfection of chicken vinculin cDNA into two tumor cell lines expressing diminished levels of the endogenous protein, brought about a drastic suppression of their tumorigenic ability. The SV-40-transformed Balb/c 3T3 line (SVT2) contains four times less vinculin than the parental 3T3 cells, and the rat adenocarcinoma BSp73ASML has no detectable vinculin. Restoration of vinculin in these cells, up to the levels found in 3T3 cells, resulted in an apparent increase in substrate adhesiveness, a decrease in the ability to grow in soft agar, and suppression of their capacity to develop tumors after injection into syngeneic hosts or nude mice. These results suggest that vinculin, a cytoplasmic component of cell-matrix and cell-cell adhesions, may have a major suppressive effect on the transformed phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.