ReviewJournal of cancer research and clinical oncology1992
Primary central nervous system lymphomas--an update.
Review in Journal of cancer research and clinical oncology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 150 citations in OpenAlex.
- Neuroimaging in the diagnosis and treatment of cerebral toxoplasmosis in children with severe β-thalassemia after allo-HSCT.Biomolecules & biomedicine · 2025Review
- Radiotherapy for newly diagnosed primary central nervous system lymphoma: role and perspective.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023Review
- Curative effect of methotrexate combined with teniposide in the treatment of primary central nervous system lymphoma.Oncology letters · 2020Article
- Observational
- Multiple secondary cauda equina non-Hodgkin's lymphoma: a case report and literature review.BMC cancer · 2019Article
- Efficacy of Perfusion Computed Tomography (PCT) in Differentiating High-Grade Gliomas from Low Grade Gliomas, Lymphomas, Metastases and Abscess.Journal of clinical and diagnostic research : JCDR · 2017Article
- A systematic approach to the diagnosis of suspected central nervous system lymphoma.JAMA neurology · 2013Review
- Dynamic CT perfusion imaging of intra-axial brain tumours: differentiation of high-grade gliomas from primary CNS lymphomas.European radiology · 2010Article
- Primary brain T-cell lymphoma of the lymphoblastic type presenting as altered mental status.Acta neurochirurgica · 2010Article
- Posterior fossa lymphoma with initial vertigo presentation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2009Article
- Primary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients.Journal of neuro-oncology · 2005Article
- Primary central nervous system lymphoma--a hospital based study of incidence and clinicopathological features from India (1980-2003).Journal of neuro-oncology · 2005Article
- Analysis of chromosomal copy number changes and oncoprotein expression in primary central nervous system lymphomas: frequent loss of chromosome arm 6q.Virchows Archiv : an international journal of pathology · 2003Article
- Long-term remission of primary central nervous system lymphoma by intensified methotrexate chemotherapy.Journal of neuro-oncology · 2003Article
- Trend of brain tumor incidence by histological subtypes in Japan: estimation from the Brain Tumor Registry of Japan, 1973-1993.Journal of neuro-oncology · 2002Article
- Primary sellar lymphoma: radiologic and pathologic findings in two patients.AJNR. American journal of neuroradiology · 2002Article
- Primary central nervous system lymphoma and subcutaneous metastases.Journal of neuro-oncology · 2000Article
- Chromosomal imbalances in primary lymphomas of the central nervous system.The American journal of pathology · 1999Article
- Classification, pathogenesis and molecular pathology of primary CNS lymphomas.Journal of neuro-oncology · 1999Review
- Primary central nervous system lymphoma: from clinical presentation to diagnosis.Journal of neuro-oncology · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary CNS lymphomas (PCNSL), until recently representing about 1% of all brain tumors, show dramatically increased incidence both in high-risk groups (immunocompromised, AIDS) and in the general population. They are extranodal diffuse non-Hodgkin's lymphomas, the morphology and classification of which are identical to those of systemic lymphomas, although PCNSL show different biological behavior and diagnosis according to the New Working Formulation and updated Kiel classification may be difficult. The majority are large B cell variants of high-grade malignancy; low-grade subtypes and T cell lymphomas are rare. Sixty per cent occur in the supratentorial space (hemispheres, periventricular) and 12% in the posterior fossa; 30% are multiple (50%-70% in AIDS). PCNSL show a male preponderance with a peak incidence in the 5th-7th decade (3rd-4th in AIDS). The duration of diffuse or focal clinical symptoms averages 1-2 months. Computed tomography and magnetic resonance imaging scans show single or multiple or diffuse, often typical lesions. Diagnosis is achieved by evaluation of stereotactic biopsy material or cerebrospinal fluid cytology using immunocytological markers. Current therapy in immunocompetent patients, radiation plus corticosteroids and pre- or postradiation polychemotherapy, shows response rates of 85% with a median survival of 17-44 months, a prognosis similar to that for glioblastoma. Meningeal PCNSL is treated with intrathecal methotrexate or cytosine arabinoside. Transliquoral seeding of PCNSL is frequent, distant metastases occurring in 6%-8%. Therapy of AIDS-related PCNSL makes use of radiation and corticosteroids, and rarely of chemotherapy. The pathogenesis of PCNSL is unknown, but Epstein-Barr virus may be a contributory factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.