ArticleInfection and immunity1992
Colony-stimulating factors activate human macrophages to inhibit intracellular growth of Histoplasma capsulatum yeasts.
Article in Infection and immunity, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 98 citations in OpenAlex.
- Utilization of amSphere · 2024Article
- The HIF-1α/LC3-II Axis Impacts Fungal Immunity in Human Macrophages.Infection and immunity · 2019Article
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- IL-4 Induces Metallothionein 3- and SLC30A4-Dependent Increase in Intracellular Zn(2+) that Promotes Pathogen Persistence in Macrophages.Cell reports · 2016Article
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- Granulocyte-macrophage colony-stimulating factor: not just another haematopoietic growth factor.Medical oncology (Northwood, London, England) · 2014Review
- Article
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- Discovery of a role for Hsp82 in Histoplasma virulence through a quantitative screen for macrophage lethality.Infection and immunity · 2011Article
- Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defenses.The Journal of infectious diseases · 2010Article
- The Histoplasma capsulatum vacuolar ATPase is required for iron homeostasis, intracellular replication in macrophages and virulence in a murine model of histoplasmosis.Molecular microbiology · 2008Article
- Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs.Journal of leukocyte biology · 2008Article
- Human dendritic cell activity against Histoplasma capsulatum is mediated via phagolysosomal fusion.Infection and immunity · 2005Article
- Absence of interleukin-4 determines less severe pulmonary paracoccidioidomycosis associated with impaired Th2 response.Infection and immunity · 2004Article
- Recombinant murine granulocyte-macrophage colony-stimulating factor modulates the course of pulmonary histoplasmosis in immunocompetent and immunodeficient mice.Antimicrobial agents and chemotherapy · 2000Article
- The URA5 gene is necessary for histoplasma capsulatum growth during infection of mouse and human cells.Infection and immunity · 1999Article
- Vbeta4(+) T cells promote clearance of infection in murine pulmonary histoplasmosis.The Journal of clinical investigation · 1998Article
- Modulation of the effector function of human macrophages for Histoplasma capsulatum by HIV-1. Role of the envelope glycoprotein gp120.The Journal of clinical investigation · 1997Article
- Intrapulmonary response to Histoplasma capsulatum in gamma interferon knockout mice.Infection and immunity · 1997Article
- Interleukin-12 modulates the protective immune response in SCID mice infected with Histoplasma capsulatum.Infection and immunity · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Recombinant cytokines and colony-stimulating factors (CSFs) were tested for their abilities to activate human monocytes/macrophages (M phi) to inhibit the intracellular growth of or kill Histoplasma capsulatum yeasts. None of the cytokines or CSFs or combinations of cytokines and CSFs activated M phi fungistatic activity when they were added to M phi monolayers concurrently with yeasts. In contrast, culture of monocytes for 7 days in the presence of interleukin 3, granulocyte-M phi CSF, or M phi CSF stimulated M phi fungistatic (but not fungicidal) activity against H. capsulatum yeasts in a concentration-dependent manner. Optimal activation of M phi by CSFs required 5 days of coculture, and the cultures had to be initiated with freshly isolated peripheral blood monocytes. Culture of monocytes with combinations of CSFs or addition of CSFs during the 24 h of coculture with the yeasts did not further enhance M phi fungistatic activity for H. capsulatum. Addition of gamma interferon or tumor necrosis factor alpha to CSF-activated M phi also did not enhance M phi fungistatic activity. These results suggest that interleukin 3, granulocyte-M phi CSF, and M phi CSF may play a role in the cell-mediated immune response to H. capsulatum by enhancing monocyte/M phi fungistatic activity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.