ArticleInfection and immunity1992
Identification of a 58-kilodalton cell surface fibrinogen-binding mannoprotein from Candida albicans.
Article in Infection and immunity, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 110 citations in OpenAlex.
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- Pathophysiology, Treatment, and Prevention of Catheter-Associated Urinary Tract Infection.Topics in spinal cord injury rehabilitation · 2019Review
- Fibrinogen Release and Deposition on Urinary Catheters Placed during Urological Procedures.The Journal of urology · 2016Article
- Integrin αXβ₂ is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Candida albicans scavenges host zinc via Pra1 during endothelial invasion.PLoS pathogens · 2012Article
- Regulation of innate immune response to Candida albicans infections by αMβ2-Pra1p interaction.Infection and immunity · 2011Article
- The pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion.The Journal of biological chemistry · 2011Article
- A proteomic analysis of secretory proteins of a pre-vacuolar mutant of Candida albicans.Journal of proteomics · 2009Article
- A proteomic-based approach for the identification of immunodominant Cryptococcus neoformans proteins.Proteomics · 2009Article
- Effect of tunicamycin on Candida albicans biofilm formation and maintenance.The Journal of antimicrobial chemotherapy · 2009Article
- Candida albicans cell wall proteins.Microbiology and molecular biology reviews : MMBR · 2008Review
- Analysis of PRA1 and its relationship to Candida albicans- macrophage interactions.Infection and immunity · 2008Article
- MNN5 encodes an iron-regulated alpha-1,2-mannosyltransferase important for protein glycosylation, cell wall integrity, morphogenesis, and virulence in Candida albicans.Eukaryotic cell · 2006Article
- Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence.The Journal of biological chemistry · 2005Article
- Microevolution of Candida albicans strains during catheter-related candidemia.Journal of clinical microbiology · 2004Article
- Tissue invasiveness and non-acidic pH in human candidiasis correlate with "in vivo" expression by Candida albicans of the carbohydrate epitope recognised by new monoclonal antibody 1H4.Journal of clinical pathology · 2004Article
- The Golgi GDPase of the fungal pathogen Candida albicans affects morphogenesis, glycosylation, and cell wall properties.Eukaryotic cell · 2002Article
- Biofilm production by isolates of Candida species recovered from nonneutropenic patients: comparison of bloodstream isolates with isolates from other sources.Journal of clinical microbiology · 2002Article
- Identification of continuous B-cell epitopes on the protein moiety of the 58-kiloDalton cell wall mannoprotein of Candida albicans belonging to a family of immunodominant fungal antigens.Infection and immunity · 2001Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment of both yeast (blastoconidia) and hyphal (blastoconidia with germ tubes) cells of Candida albicans with beta-mercaptoethanol (beta ME) releases a complex array of cell wall-bound proteins and glycoproteins. Analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western immunoblotting with fibrinogen-anti-fibrinogen antibody allowed the identification of a 58-kDa mannoprotein (mp58) in both extracts which specifically interacts with human fibrinogen. Treatment of intact cells with low concentrations of beta-glucanase (Zymolyase 20T) for short periods or with beta ME abolished or significantly reduced binding of fibrinogen. A rabbit polyclonal antiserum was raised against the purified mp58 species released by beta ME from germinated blastoconidia (PAb anti-mp58). By Western blotting, the antiserum cross-reacted with the homologous 58-kDa fibrinogen-binding mannoprotein present in beta ME extracts from blastoconidia, and by indirect immunofluorescence, the antiserum labelled both yeast cells and hyphae, yet reactivity was found primarily on the cell surface of filamentous forms. Immunostaining of human infected tissue sections with PAb anti-mp58 showed that the mp58 species is also expressed in vivo; in this case, the species is in the forms of both yeast and hyphal elements similarly labelled by the antiserum. Purified immunoglobulin G fraction from the antiserum did not alter the binding of fibrinogen as determined by a modified enzyme-linked immunosorbent assay and Western blotting. The N- and O-glycosidically linked carbohydrates represent 18 to 20% and 3 to 4%, respectively, of the molecular mass of the mp58. O-linked sugar residues may be involved in the interaction of the molecule with fibrinogen.
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