ArticleImmunology1992
Down-regulation of a spontaneous arthritis in male DBA/1 mice after administration of monoclonal anti-idiotypic antibodies to a cross-reactive idiotope on anti-collagen antibodies.
Article in Immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 7 citations in OpenAlex.
- Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis.The Journal of clinical investigation · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently described a spontaneously occurring, inflammatory and erosive joint disease in male DBA/1 mice. A major question is whether specific immune reactions are involved in eliciting this disease. The possibility that collagen autoimmunity might constitute one pathogenic factor was particularly interesting as this spontaneous arthritis appears to be genetically restricted in a way similar to collagen-induced arthritis. In the present study, we demonstrate increased serum antibody levels to collagen II in a fraction of the male DBA/1 mice, but not in age-matched female controls. Administration of antibodies with an anti-idiotypic activity to anti-collagen II antibodies and with an affinity for determinants present on isolated syngeneic IgG Fc but not on intact IgG, was shown to interfere with the development of the spontaneous arthritis in a manner similar to that earlier documented for collagen arthritis. These observations suggest that mechanisms similar to those operating in collagen-induced arthritis may also be found in the spontaneously occurring arthritis in male DBA/1 mice.
Indexed as
Identifiers
1398761PMC1421579W4399875What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.