ArticleGenetics1992
Simulation study of a multigene family, with special reference to the evolution of compensatory advantageous mutations.
Article in Genetics, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Molecular Evolution and Organization of Ribosomal DNA in the Hawkweed Tribe Hieraciinae (Cichorieae, Asteraceae).Frontiers in plant science · 2021Article
- Retention of functional variation despite extreme genomic erosion: MHC allelic repertoires in the Lynx genus.BMC evolutionary biology · 2017Article
- A generalized birth and death process for modeling the fates of gene duplication.BMC evolutionary biology · 2015Article
- Tomato (Biotechnology, biotechnological equipment · 2014Article
- A Bayesian model for gene family evolution.BMC bioinformatics · 2011Article
- Two classes of 5S rDNA unit arrays of the silver fir, Abies alba Mill.: structure, localization and evolution.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2005Article
- What happens to genes in duplicated genomes.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Article
- Comparable rates of gene loss and functional divergence after genome duplications early in vertebrate evolution.Genetics · 1997Article
- Polymorphism and concerted evolution in a tandemly repeated gene family: 5S ribosomal DNA in diploid and allopolyploid cottons.Journal of molecular evolution · 1996Article
- Gene conversion vs point mutation in generating variability at the antigen recognition site of major histocompatibility complex loci.Journal of molecular evolution · 1995Article
- How often do duplicated genes evolve new functions?Genetics · 1995Article
- Pattern of nucleotide substitutions in growth hormone-prolactin gene family: a paradigm for evolution by gene duplication.Genetics · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigate the evolution of a multigene family incorporating the forces of drift, mutation, gene conversion, unequal crossing over and selection. The use of simulation studies is required due to the complexity of the model. Selection is modeled in two modes: positive selection as a function of the number of different beneficial alleles and negative selection against deleterious alleles. We assume that gene conversion is unbiased, and that all mutations are initially deleterious. Compensation between mutants creates beneficial and neutral alleles, and allowances are made for compensatory mutations either within or between the members of a multigene family. We find that gene conversion can enhance the rate of acquisition of compensatory advantageous mutations when genes are redundant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.