ArticleBritish journal of pharmacology1992
Effect of MgATP on pinacidil-induced displacement of glibenclamide from the sulphonylurea receptor in a pancreatic beta-cell line and rat cerebral cortex.
Article in British journal of pharmacology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
- Interaction of sulphonylurea derivatives with vascular ATP-sensitive potassium channels in humans.Diabetologia · 1996Trial
- KATP Channels in the Cardiovascular System.Physiological reviews · 2016Review
- Two neonatal diabetes mutations on transmembrane helix 15 of SUR1 increase affinity for ATP and ADP at nucleotide binding domain 2.The Journal of biological chemistry · 2012Article
- Some cannabinoid receptor ligands and their distomers are direct-acting openers of SUR1 K(ATP) channels.American journal of physiology. Endocrinology and metabolism · 2012Article
- Advances in molecular imaging of pancreatic beta cells.Frontiers in bioscience : a journal and virtual library · 2008Article
- KATP channel openers of the benzopyran type reach their binding site via the cytosol.British journal of pharmacology · 2006Article
- ATP-sensitive potassium channel (KATP channel) expression in the normal canine pancreas and in canine insulinomas.BMC veterinary research · 2005Article
- The mutation Y1206S increases the affinity of the sulphonylurea receptor SUR2A for glibenclamide and enhances the effects of coexpression with Kir6.2.British journal of pharmacology · 2005Article
- Interaction of a novel dihydropyridine K+ channel opener, A-312110, with recombinant sulphonylurea receptors and KATP channels: comparison with the cyanoguanidine P1075.British journal of pharmacology · 2004Article
- Binding and effect of K ATP channel openers in the absence of Mg2+.British journal of pharmacology · 2003Article
- Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides.British journal of pharmacology · 2002Article
- Synthesis and characterization of a novel tritiated KATP channel opener with a benzopyran structure.British journal of pharmacology · 2001Article
- Structural requirements of sulphonylureas and analogues for interaction with sulphonylurea receptor subtypes.British journal of pharmacology · 1999Article
- Regional and species differences in glyburide-sensitive K+ channels in airway smooth muscles as estimated from actions of KC 128 and levcromakalim.British journal of pharmacology · 1994Article
- Location of the sulphonylurea receptor at the cytoplasmic face of the beta-cell membrane.British journal of pharmacology · 1994Article
- Interaction of tolbutamide and cytosolic nucleotides in controlling the ATP-sensitive K+ channel in mouse beta-cells.British journal of pharmacology · 1994Article
- Antagonism of the stimulatory effects of efaroxan and glibenclamide in rat pancreatic islets by the imidazoline, RX801080.British journal of pharmacology · 1993Article
- Diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel in mouse pancreatic beta-cells.British journal of pharmacology · 1992Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effects of blockers and openers of K+ channels on binding of [3H]-glibenclamide to microsomes obtained from a pancreatic beta-cell line (HIT-T15) or rat cerebral cortex were examined. 2. The blockers quinine, chlorpromazine and thiopentone and the openers cromakalim [(+/- ) 6-cyano-3,4-dihydro-2,2-dimethyl-trans-4-(2-oxo-1- pyrrolidyl)-2H-benzo[b]pyran-3-ol] and minoxidil sulphate did not significantly interact with the sulphonylurea receptor of HIT-cells both at phosphorylating (presence of MgATP) and dephosphorylating (absence of MgATP) conditions. 3. In the absence of MgATP, pinacidil (200-500 microM) did not significantly displace [3H]-glibenclamide binding to microsomes from HIT-cells. The displacement of [3H]-glibenclamide binding was strongly enhanced by MgATP and was due to a decrease in the number of high affinity binding sites for glibenclamide. 4. MgATP enhanced pinacidil-induced inhibition of [3H]-glibenclamide binding to microsomes from rat cerebral cortex. 5. The effect of MgATP on pinacidil-induced inhibition of [3H]-glibenclamide binding was maintained after solubilization of the membranes from HIT-cells or rat cerebral cortex. 6. It is concluded that the sulphonylurea receptor is regulated not only by sulphonylureas but also by the K+ channel openers, diazoxide and pinacidil, and by protein phosphorylation. The binding sites for sulphonylureas and these K+ channel openers are not identical, but appear to be located at a single protein or at tightly associated proteins.
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