ArticleBMJ (Clinical research ed.)1992
Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports.
Article in BMJ (Clinical research ed.), 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
108 citing papers in PubMed, 3 syntheses or guidelines pooled it, 582 citations in OpenAlex.
- Pooled it
- Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012.Intensive care medicine · 2013Guideline
- Consensus guidelines on sedation and analgesia in critically ill children.Intensive care medicine · 2006Guideline
- Pilot study in humans on the pharmacokinetics and safety of propofol 6% SAZN.Pharmacy world & science : PWS · 1999Trial
- Pharmacokinetics, induction of anaesthesia and safety characteristics of propofol 6% SAZN vs propofol 1% SAZN and Diprivan-10 after bolus injection.British journal of clinical pharmacology · 1999Trial
- Perioperative Continuous Propofol Infusion in the Pediatric Cardiac Intensive Care Unit: A 25-Year Retrospective Study.Pediatric cardiology · 2026Article
- Characterizing the Safety and Efficacy of Propofol in Critically Ill Pediatric Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- Propofol-Related Infusion Syndrome in Paediatrics-Cautious Consideration or Considered Caution? Case Report.Journal of paediatrics and child health · 2026Article
- Targetable Effects of the Anesthetic, Ubiquinone-5, on Murine Cardiac Rhythm.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Sedation in Critically Ill Children.Journal of clinical medicine · 2025Review
- Propofol-related biological alterations and incidence of propofol infusion syndrome in status epilepticus: a 10-year cohort study.Frontiers in neurology · 2025Article
- Article
- In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs.Current issues in molecular biology · 2024Article
- Refractory atrial fibrillation with rapid ventricular response as a heralding sign of propofol infusion syndrome in a patient with COVID-19.BMJ case reports · 2023Article
- Characterization of Propofol Use For Non-Procedural Sedation in a Pediatric Intensive Care Unit.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia?BioMed research international · 2023Review
- What Is Known about Midazolam? A Bibliometric Approach of the Literature.Healthcare (Basel, Switzerland) · 2022Review
- Propofol toxicity in the developing mouse heart mitochondria.Pediatric research · 2022Article
- Review
- Modeling propofol-induced cardiotoxicity in the isolated-perfused newborn mouse heart.Physiological reports · 2022Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the possible contribution of sedation with propofol in the deaths of children who were intubated and required intensive care.
designCase note review.
settingThree intensive care units. SUBJECTS: Five children with upper respiratory tract infections aged between 4 weeks and 6 years.
resultsFour patients had laryngotracheo-bronchitis and one had bronchiolitis. All were sedated with propofol. The clinical course in all five cases was remarkably similar: an increasing metabolic acidosis was associated with brady-arrhythmia and progressive myocardial failure, which did not respond to resuscitative measures. All children developed lipaemic serum after starting propofol. These features are not usually associated with respiratory tract infections. No evidence was found of viral myocarditis, which was considered as a possible cause of death.
conclusionAlthough the exact cause of death in these children could not be defined, propofol may have been a contributing factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.