Evidence map›Paper›PMID 1392706›Full record

ArticleBMJ (Clinical research ed.)1992

Relation of infant feeding to adult serum cholesterol concentration and death from ischaemic heart disease.

C H Fall, D J Barker, C Osmond, P D Winter, P M Clark, C N Hales

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 2 pooled it
29.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 368 citations in OpenAlex.

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  19. Placental Origins of Chronic Disease.Physiological reviews · 2016
    Review
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

C H FallMRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital.
D J Barker
C Osmond
P D Winter
P M Clark
C N Hales
Southampton General Hospital · GBUniversity of Southampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine whether method of infant feeding is associated with adult serum lipid concentrations and mortality from ischaemic heart disease.

designFollow up study of men born during 1911-30.

settingHertfordshire, England. SUBJECTS: 5718 men, for 5471 of whom information on infant feeding had been recorded by health visitors and 1314 of whom had died. 485 of the men born during 1920-30 and still living in Hertfordshire who had blood lipid measurements.

main outcome measuresDeath from ischaemic heart disease; serum cholesterol and apolipoprotein concentrations.

results474 men had died from ischaemic heart disease. Standardised mortality ratios were 97 (95% confidence interval 81 to 115) in men who had been breast fed and had not been weaned at 1 year, 79 (69 to 90) in breast fed men who had been weaned at 1 year, and 73 (59 to 89) in men who had been breast and bottle fed. Compared with men weaned before one year men not weaned had higher mean serum concentrations of total cholesterol (6.9 (not weaned) v 6.6 (weaned) mmol/l), low density lipoprotein cholesterol (5.0 v 4.6 mmol/l) and apolipoprotein B (1.14 v 1.08 g/l). Men who had been bottle fed also had a high standardised mortality ratio for ischaemic heart disease (95; 68 to 130) and high mean serum concentrations of total cholesterol (7.0 mmol/l), low density lipoprotein cholesterol (5.1 mmol/l), and apolipoprotein B (1.14 g/l). In all feeding groups serum apolipoprotein B concentrations were lower in men with higher birth weight and weight at 1 year.

conclusionsAge of weaning and method of infant feeding may influence adult serum low density lipoprotein cholesterol concentrations and mortality from ischaemic heart disease. Adult serum apolipoprotein B concentrations are related to growth in fetal life and infancy.

Indexed as

Infant Nutritional Physiological PhenomenaAgedAged, 80 and overAge FactorsApolipoproteins BBody WeightBottle FeedingBreast FeedingCholesterolCholesterol, LDLCoronary DiseaseFollow-Up StudiesHumansInfantInfant, NewbornMaleApolipoproteins BCholesterolCholesterol, LDL

Identifiers

PMID1392706
PMCPMC1881689
OpenAlexW2060921297

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.