ArticleMolecular biology of the cell1992
A mutant nuclear protein with similarity to RNA binding proteins interferes with nuclear import in yeast.
Article in Molecular biology of the cell, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed, 120 citations in OpenAlex.
- RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing.Nature communications · 2023Article
- The RGG motif proteins: Interactions, functions, and regulations.Wiley interdisciplinary reviews. RNA · 2023Review
- The SR-protein FgSrp2 regulates vegetative growth, sexual reproduction and pre-mRNA processing by interacting with FgSrp1 in Fusarium graminearum.Current genetics · 2020Article
- A Nuclear Export Block Triggers the Decay of Newly Synthesized Polyadenylated RNA.Cell reports · 2018Article
- The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons.Cell reports · 2017Article
- Post-translational modification directs nuclear and hyphal tip localization of Candida albicans mRNA-binding protein Slr1.Molecular microbiology · 2017Article
- Stress-induced nuclear-to-cytoplasmic translocation of cyclin C promotes mitochondrial fission in yeast.Developmental cell · 2014Article
- Npl3, a new link between RNA-binding proteins and the maintenance of genome integrity.Cell cycle (Georgetown, Tex.) · 2014Article
- SR-like RNA-binding protein Slr1 affects Candida albicans filamentation and virulence.Infection and immunity · 2013Article
- Protein arginine methylation facilitates cotranscriptional recruitment of pre-mRNA splicing factors.Molecular and cellular biology · 2010Article
- Autoregulation of Npl3, a yeast SR protein, requires a novel downstream region and serine phosphorylation.Molecular and cellular biology · 2008Article
- Snu56p is required for Mer1p-activated meiotic splicing.Molecular and cellular biology · 2008Article
- Protein arginine methylation in Candida albicans: role in nuclear transport.Eukaryotic cell · 2007Article
- The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles.Genetics · 2006Article
- Nuclear export of hnRNP Hrp1p and nuclear export of hnRNP Npl3p are linked and influenced by the methylation state of Npl3p.Molecular and cellular biology · 2004Article
- The yeast hnRNP-like protein Hrp1/Nab4 sccumulates in the cytoplasm after hyperosmotic stress: a novel Fps1-dependent response.Molecular biology of the cell · 2003Article
- In vivo analysis of nucleolar proteins modified by the yeast arginine methyltransferase Hmt1/Rmt1p.RNA (New York, N.Y.) · 2003Article
- The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation.Molecular biology of the cell · 2001Article
- Messenger RNAs are recruited for nuclear export during transcription.Genes & development · 2001Article
- A genomic study of the bipolar bud site selection pattern in Saccharomyces cerevisiae.Molecular biology of the cell · 2001Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have isolated mutants of the yeast Saccharomyces cerevisiae that are defective in localization of nuclear proteins. Chimeric proteins containing the nuclear localization sequence from SV40 large T-antigen fused to the N-terminus of the mitochondrial F1 beta-ATPase are localized to the nucleus. Npl (nuclear protein localization) mutants were isolated by their ability to grow on glycerol as a consequence of no longer exclusively targeting SV40-F1 beta-ATPase to the nucleus. All mutants with defects in localization of nucleolar proteins and histones are temperature sensitive for growth at 36 degrees C. Seven alleles of NPL3 and single alleles of several additional genes were isolated. NPL3 mutants were studied in detail. NPL3 encodes a nuclear protein with an RNA recognition motif and similarities to a family of proteins involved in RNA metabolism. Our genetic analysis indicates that NPL3 is essential for normal cell growth; cells lacking NPL3 are temperature sensitive for growth but do not exhibit a defect in localization of nuclear proteins. Taken together, these results indicate that the mutant forms of Npl3 protein isolated by this procedure are interfering with nuclear protein uptake in a general manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.