ArticleProceedings of the National Academy of Sciences of the United States of America1992
Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Review
- Arginine methylation of hnRNP A2 does not directly govern its subcellular localization.PloS one · 2013Article
- Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles.RNA (New York, N.Y.) · 2010Review
- iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution.Nature structural & molecular biology · 2010Article
- Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila.PLoS genetics · 2009Article
- Specific combinations of SR proteins associate with single pre-messenger RNAs in vivo and contribute different functions.The Journal of cell biology · 2009Article
- Functional analysis of SNF, the Drosophila U1A/U2B" homolog: identification of dispensable and indispensable motifs for both snRNP assembly and function in vivo.RNA (New York, N.Y.) · 1999Article
- Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization.The EMBO journal · 1999Article
- Arginine methylation and binding of Hrp1p to the efficiency element for mRNA 3'-end formation.RNA (New York, N.Y.) · 1999Article
- Ultrastructural analysis of transcription and splicing in the cell nucleus after bromo-UTP microinjection.Molecular biology of the cell · 1999Article
- Separable roles in vivo for the two RNA binding domains of Drosophila A1-hnRNP homolog.RNA (New York, N.Y.) · 1998Article
- Analysis of the functional specificity of RS domains in vivo.The EMBO journal · 1998Article
- Sex-lethal interacts with splicing factors in vitro and in vivo.Molecular and cellular biology · 1996Article
- Multiparameter microscopic analysis of nucleolar structure and ribosomal gene transcription.Histochemistry and cell biology · 1996Review
- Altered levels of the Drosophila HRB87F/hrp36 hnRNP protein have limited effects on alternative splicing in vivo.Molecular biology of the cell · 1996Article
- A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export.The Journal of cell biology · 1996Article
- A discrete 3' region of U6 small nuclear RNA modulates the phosphorylation cycle of the C1 heterogeneous nuclear ribonucleoprotein particle protein.Molecular and cellular biology · 1996Article
- Potential RNA binding proteins in Saccharomyces cerevisiae identified as suppressors of temperature-sensitive mutations in NPL3.Genetics · 1996Article
- Assembly and disassembly of spliceosomes along a specific pre-messenger RNP fiber.The EMBO journal · 1994Article
- Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae.The Journal of cell biology · 1994Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major nuclear ribonucleoproteins (RNPs) involved in pre-mRNA processing are classified in broad terms either as small nuclear RNPs (snRNPs), which are major participants in the splicing reaction, or heterogeneous nuclear RNPs (hnRNPs), which traditionally have been thought to function in general pre-mRNA packaging. We obtained antibodies that recognize these two classes of RNP in Drosophila melanogaster. Using a sequential immunostaining technique to compare directly the distribution of these RNPs on Drosophila polytene chromosomes, we found that the two patterns were very similar qualitatively but not quantitatively, arguing for the independent deposition of the two RNP types and supporting a role for hnRNP proteins, but not snRNPs, in general transcript packaging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.