ArticleCurrent genetics1992
A single amino-acid substitution in the beta-tubulin gene of Neurospora confers both carbendazim resistance and diethofencarb sensitivity.
Article in Current genetics, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 70 citations in OpenAlex.
- Nationwide Distribution and Fungicide Resistance of Colletotrichum Species Causing Apple Bitter Rot in Korea (2015-2024).The plant pathology journal · 2026Article
- Research Progress on Benzimidazole Fungicides: A Review.Molecules (Basel, Switzerland) · 2024Review
- Refugia or reservoir? Feral goats and their role in the maintenance and circulation of benzimidazole-resistant gastrointestinal nematodes on shared pastures.Parasitology · 2023Article
- Experimental Evolution of Multidrug Resistance inJournal of fungi (Basel, Switzerland) · 2022Article
- Dual Impact of a Benzimidazole Resistant β-Tubulin on Microtubule Behavior in Fission Yeast.Cells · 2021Article
- New codon 198 β-tubulin polymorphisms in highly benzimidazole resistant Haemonchus contortus from goats in three different states in Sudan.Parasites & vectors · 2020Article
- CRISPR-Cas9 ribonucleoprotein-mediated co-editing and counterselection in the rice blast fungus.Scientific reports · 2018Article
- Analysis of β-tubulin-carbendazim interaction reveals that binding site for MBC fungicides does not include residues involved in fungicide resistance.Scientific reports · 2018Article
- Molecular characterization of beta-tubulin from Phakopsora pachyrhizi, the causal agent of Asian soybean rust.Genetics and molecular biology · 2010Article
- Mutations in a beta-tubulin disrupt spindle orientation and microtubule dynamics in the early Caenorhabditis elegans embryo.Molecular biology of the cell · 2003Article
- Molecular basis for fungal selectivity of novel antimitotic compounds.Antimicrobial agents and chemotherapy · 2003Article
- Effect of auristatin PHE on microtubule integrity and nuclear localization in Cryptococcus neoformans.Antimicrobial agents and chemotherapy · 2002Article
- Structure-function relationships in yeast tubulins.Molecular biology of the cell · 2000Article
- Fungal beta-tubulin, expressed as a fusion protein, binds benzimidazole and phenylcarbamate fungicides.Antimicrobial agents and chemotherapy · 1998Article
- Isolation, characterization, and expression of a second beta-tubulin-encoding gene from Colletotrichum gloeosporioides f. sp. aeschynomene.Applied and environmental microbiology · 1994Article
- Amino-acid alterations in the beta-tubulin gene of Neurospora crassa that confer resistance to carbendazim and diethofencarb.Current genetics · 1994Article
- A nucleotide substitution in one of the beta-tubulin genes of Trichoderma viride confers resistance to the antimitotic drug methyl benzimidazole-2-yl-carbamate.Molecular & general genetics : MGG · 1993Article
- The Neurospora uvs-2 gene encodes a protein which has homology to yeast RAD18, with unique zinc finger motifs.Molecular & general genetics : MGG · 1993Article
- Molecular analysis of the Septoria nodorum beta-tubulin gene and characterization of a benomyl-resistance mutation.Molecular & general genetics : MGG · 1993Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two MBC-resistant mutants of Neurospora crassa, F914 and F939, were sensitive to diethofencarb at a concentration of 0.1 micrograms/ml, while the wild-type strain and other MBC-resistant mutants showed resistance to diethofencarb at a concentration of 100 micrograms/ml. Genetic analysis suggested that the mutations in these two strain were closely linked to the Bml locus which codes for beta-tubulin. When the wild-type strain was transformed by the cloned beta-tubulin gene of the F914 strain, the transformants showed both MBC resistance and diethofencarb sensitivity. On the other hand, the diethofencarb sensitivity of the F914 strain was cancelled by transformation with the wild-type beta-tubulin gene. DNA sequencing of F914 beta-tubulin revealed that glycine was substituted for glutamic acid at position 198 in the F914 strain. Therefore, a single base change in the beta-tubulin gene was proved to confer both MBC resistance and diethofencarb sensitivity.
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