ArticleThe Journal of cell biology1992
Phosphorylation of myosin-II regulatory light chain by cyclin-p34cdc2: a mechanism for the timing of cytokinesis.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 194 citations in OpenAlex.
- CDK signaling via nonconventional CDK phosphorylation sites.Molecular biology of the cell · 2023Review
- Growth-Regulated Hsp70 Phosphorylation Regulates Stress Responses and Prion Maintenance.Molecular and cellular biology · 2020Article
- Review
- Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives.European biophysics journal : EBJ · 2016Review
- Myosin di-phosphorylation and peripheral actin bundle formation as initial events during endothelial barrier disruption.Scientific reports · 2016Article
- Article
- Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement.Nature cell biology · 2015Article
- Identification of non-Ser/Thr-Pro consensus motifs for Cdk1 and their roles in mitotic regulation of C2H2 zinc finger proteins and Ect2.Scientific reports · 2015Article
- Tumor treating fields perturb the localization of septins and cause aberrant mitotic exit.PloS one · 2015Article
- Manipulation of endogenous kinase activity in living cells using photoswitchable inhibitory peptides.ACS synthetic biology · 2014Article
- Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular motor.The Journal of biological chemistry · 2014Article
- Cloning and molecular characterization of a myosin light chain gene from Puccinia striiformis f. sp. tritici.World journal of microbiology & biotechnology · 2014Article
- Orbit/CLASP is required for myosin accumulation at the cleavage furrow in Drosophila male meiosis.PloS one · 2014Article
- Notch transcriptional control of vascular smooth muscle regulatory gene expression and function.The Journal of biological chemistry · 2013Article
- Rho kinase signaling pathways during stretch in primary alveolar epithelia.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Article
- Understanding cytokinesis failure.Advances in experimental medicine and biology · 2010Review
- Role of the RNA-binding protein Nrd1 and Pmk1 mitogen-activated protein kinase in the regulation of myosin mRNA stability in fission yeast.Molecular biology of the cell · 2009Article
- The IQGAP Iqg1 is a regulatory target of CDK for cytokinesis in Candida albicans.The EMBO journal · 2008Article
- The phosphorylation of myosin II at the Ser1 and Ser2 is critical for normal platelet-derived growth factor induced reorganization of myosin filaments.Molecular biology of the cell · 2007Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
To understand how cytokinesis is regulated during mitosis, we tested cyclin-p34cdc2 for myosin-II kinase activity, and investigated the mitotic-specific phosphorylation of myosin-II in lysates of Xenopus eggs. Purified cyclin-p34cdc2 phosphorylated the regulatory light chain of cytoplasmic and smooth muscle myosin-II in vitro on serine-1 or serine-2 and threonine-9, sites known to inhibit the actin-activated myosin ATPase activity of smooth muscle and nonmuscle myosin (Nishikawa, M., J. R. Sellers, R. S. Adelstein, and H. Hidaka. 1984. J. Biol. Chem. 259:8808-8814; Bengur, A. R., A. E. Robinson, E. Appella, and J. R. Sellers. 1987. J. Biol. Chem. 262:7613-7617; Ikebe, M., and S. Reardon. 1990. Biochemistry. 29:2713-2720). Serine-1 or -2 of the regulatory light chain of Xenopus cytoplasmic myosin-II was also phosphorylated in Xenopus egg lysates stabilized in metaphase, but not in interphase. Inhibition of myosin-II by cyclin-p34cdc2 during prophase and metaphase could delay cytokinesis until chromosome segregation is initiated and thus determine the timing of cytokinesis relative to earlier events in mitosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.