Evidence map›Paper›PMID 1386347›Full record

ArticleInfection and immunity1992

Cell extracts of Candida albicans block adherence of the organisms to endothelial cells.

J E Edwards, C L Mayer, S G Filler, E Wadsworth, R A Calderone

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

J E EdwardsDepartment of Medicine, Harbor/UCLA Medical Center, Torrance 90509.
C L Mayer
S G Filler
E Wadsworth
R A Calderone
UCLA Medical Center · US

Funding

CANDIDA ADHERENCE &PENETRATION--VASCULAR ENDOTHELIUMR01AI019990 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI EDWARDS, JOHN E · 1986 to 2009
$2.5M
Candida Adherence &Penetration of Vascular EndotheliumR21AI019990 · NIAID · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI EDWARDS, JOHN E. · 2003 to 2003
$354k
C3D COMPLEMENT RECEPTOR OF CANDIDA ALBICANSR01AI025738 · NIAID · GEORGETOWN UNIVERSITY · PI CALDERONE, RICHARD ARTHUR · 1987 to 1994
–
PATHOGENESIS OF ENDOCARDITIS CAUSED BY CANDIDA ALBICANSR01HL021370 · NHLBI · GEORGETOWN UNIVERSITY · PI CALDERONE, RICHARD ARTHUR · 1985 to 1992
–
NHLBI NIH HHS HLB-21370NIAID NIH HHS AI-19990NIAID NIH HHS AI-25738
6 · The paper itself

Abstract

Cell extracts of Candida albicans were fractionated by concanavalin A affinity chromatography. Eluted mannosylated proteins (fraction II) and nonbinding, nonmannosylated proteins (fraction I) were collected and assayed directly for inhibition of adherence of C. albicans to endothelium. Fraction II blocked blastospore adherence to endothelial cells. Fraction I blocked both blastospore and germ tube adherence to endothelial cells. Monoclonal antibody OKM-1 (anti-CR3) and an anti-C. albicans monoclonal antibody, CA-A (anti-CR2), reacted in Western blots with proteins from fraction I, suggesting the presence of the CR2- and CR3-like proteins that have been previously identified on C. albicans germ tubes.

Indexed as

AdhesivenessAntigens, Differentiation, B-LymphocyteBlotting, WesternCandida albicansCell WallEndothelium, VascularHumansMacrophage-1 AntigenReceptors, ComplementReceptors, Complement 3dAntigens, Differentiation, B-LymphocyteMacrophage-1 AntigenReceptors, ComplementReceptors, Complement 3d

Identifiers

PMID1386347
PMCPMC257285
OpenAlexW1904100768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.