ArticleThe EMBO journal1992
Differential occurrence of CSF-like activity and transforming activity of Mos during the cell cycle in fibroblasts.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.The EMBO journal · 2010Article
- Sp1 mediates cell proliferation-dependent regulation of rat DNA topoisomerase IIalpha gene promoter.The Biochemical journal · 1999Article
- Mos positively regulates Xe-Wee1 to lengthen the first mitotic cell cycle of Xenopus.Genes & development · 1999Article
- The casein kinase II beta subunit binds to Mos and inhibits Mos activity.Molecular and cellular biology · 1997Article
- Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins.Molecular and cellular biology · 1997Article
- The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase.The EMBO journal · 1996Article
- Regulation of Raf-1-dependent signaling during early Xenopus development.Molecular and cellular biology · 1995Article
- The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.The EMBO journal · 1995Article
- Cyclins and cyclin-dependent kinases: a biochemical view.The Biochemical journal · 1995Review
- Degradation of Mos by the N-terminal proline (Pro2)-dependent ubiquitin pathway on fertilization of Xenopus eggs: possible significance of natural selection for Pro2 in Mos.The EMBO journal · 1993Article
- Mos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cells.Molecular biology of the cell · 1993Article
- The 'second-codon rule' and autophosphorylation govern the stability and activity of Mos during the meiotic cell cycle in Xenopus oocytes.The EMBO journal · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Xenopus c-mos proto-oncogene product, Mosxe, possesses cytostatic factor (CSF) activity to arrest maturing oocytes in metaphase II and has weak transforming activity in mouse NIH3T3 cells. We show that Mosxe mutants bearing 'stabilizing' penultimate N-terminal amino acids are strongly transforming and can retard progression through the G2-M phases in Mosxe-transformed cells, probably via their CSF activity. On the other hand, a cyclin-Mosxe fusion protein, which undergoes abrupt degradation at the end of mitosis and is restored to its normal levels only after the G1 phase, transforms cells much less efficiently than a mutated cyclin-Mosxe fusion protein that is stable during M-G1 transition. Moreover, in low-serum medium, cells transformed by the unstable cyclin-Mosxe require a long period to enter the S phase, in contrast with the rapid entry into the S phase of cells transformed by the stable cyclin-Mosxe. These results provide strong evidence that unlike the physiological CSF activity, the transforming activity of Mos is exerted in the G1 phase of the cell cycle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.