ArticleCell and tissue research1992
Enterochromaffin-like cells in the rat stomach: effect of alpha-fluoromethylhistidine-evoked histamine depletion. A chemical, histochemical and electron-microscopic study.
Article in Cell and tissue research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 57 citations in OpenAlex.
- What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract.Foods (Basel, Switzerland) · 2018Review
- Characterization of gastric and neuronal histaminergic populations using a transgenic mouse model.PloS one · 2013Article
- Effects ofAnnals of gastroenterology · 2012Article
- Tachyphylaxis of the ECL-cell response to PACAP: receptor desensitization and/or depletion of secretory products.British journal of pharmacology · 2007Article
- Effect of interleukin-8 on histamine release from totally isolated vascularly perfused rat stomach.Journal of gastroenterology · 2005Article
- Immunoelectron microscopic study for histamine in the gastric enterochromaffin-like cells of rats treated with the proton pump inhibitor lansoprazole.Histochemistry and cell biology · 2003Article
- Submucosal microinfusion of endothelin and adrenaline mobilizes ECL-cell histamine in rat stomach, and causes mucosal damage: a microdialysis study.British journal of pharmacology · 2003Article
- Anaesthetic agents inhibit gastrin-stimulated but not basal histamine release from rat stomach ECL cells.British journal of pharmacology · 2000Article
- Antisera against rat recombinant histidine decarboxylase: immunocytochemical studies in different species.The Histochemical journal · 1999Article
- Production of monoclonal antibody against histamine and its application to immunohistochemical study in the stomach.The Histochemical journal · 1998Article
- Pathophysiology of the fundic enterochromaffin-like (ECL) cell and gastric carcinoid tumours.Annals of the Royal College of Surgeons of England · 1996Article
- Effect of omeprazole-evoked hypergastrinemia on ultrastructure of enterochromaffin-like cells in the stomach of portacaval-shunted rats.Cell and tissue research · 1993Article
- The biology and physiology of the ECL cell.The Yale journal of biology and medicineReview
- Histamine metabolism of gastric carcinoids in Mastomys natalensis.The Yale journal of biology and medicineReview
- The biology and pathobiology of the ECL cells.The Yale journal of biology and medicineReview
- ECL cell morphology.The Yale journal of biology and medicineReview
- Physiological significance of ECL-cell histamine.The Yale journal of biology and medicineReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the rat, gastric histamine is stored predominantly in the enterochromaffin-like (ECL) cells, which are located basally in the oxyntic mucosa. The functional significance of histamine in the ECL cells is a matter of speculation. In this study the effect of depletion of histamine on the properties and ultrastructure of the ECL cells was examined. Histamine synthesis was inhibited with alpha-fluoromethylhistidine (3 mg.kg-1.h-1) given via osmotic minipumps over a period of 24 h. The treatment reduced the histidine decarboxylase activity (approximately 20% remaining) and histamine concentration (less than 20% remaining) in the oxyntic mucosa, as well as the intensity of histamine- and chromogranin A-immunostaining in the ECL cells, compared to control rats. The cytoplasmic (secretory) granules/vesicles were greatly reduced in number and size following alpha-fluoromethylhistidine administration. The histamine immunostaining of the mast cells, which occurs at the mucosal surface and in the submucosa, appeared unaffected. We conclude that ECL cell histamine accounts for at least 80% of the total oxyntic mucosal histamine in the rat and that it represents a more mobile pool than mast cell histamine. The reduction in the number and size of the ECL cell granules/vesicles following histamine depletion is in accord with the idea that they represent the storage site for histamine.
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