ArticleActa neuropathologica1992
The fate of desmin and titin during the degeneration and regeneration of the soleus muscle of the rat.
Article in Acta neuropathologica, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Alterations of the skeletal muscle contractile apparatus in necrosis induced by myotoxic snake venom phospholipases AJournal of muscle research and cell motility · 2024Review
- Mapping the Immune Cell Microenvironment with Spatial Profiling in Muscle Tissue Injected with the Venom ofToxins · 2023Article
- Does altered protein metabolism interfere with postmortem degradation analysis for PMI estimation?International journal of legal medicine · 2018Article
- Chronic Prosopis glandulosa treatment blunts neutrophil infiltration and enhances muscle repair after contusion injury.Nutrients · 2015Article
- Muscle fibre breakdown in venom-induced muscle degeneration.Journal of anatomy · 2003Article
- Degeneration and regeneration of neuromuscular junction architecture in rat skeletal muscle fibers damaged by bupivacaine hydrochloride.Journal of muscle research and cell motility · 2003Article
- Diagnostic protein expression in human muscle biopsies.Brain pathology (Zurich, Switzerland) · 2000Review
- Specific and innervation-regulated expression of the intermediate filament protein nestin at neuromuscular and myotendinous junctions in skeletal muscle.The American journal of pathology · 1999Article
- Activation of the skeletal alpha-actin promoter during muscle regeneration.Journal of muscle research and cell motility · 1998Article
- The identification of myogenic cells in skeletal muscle, with emphasis on the use of tritiated thymidine autoradiography and desmin antibodies.Journal of anatomy · 1998Review
- Desmin-lacZ transgene expression and regeneration within skeletal muscle transplants.Journal of muscle research and cell motility · 1997Article
- Changes in mRNA levels of the sarcoplasmic/endoplasmic-reticulum Ca(2+)-ATPase isoforms in the rat soleus muscle regenerating from notexin-induced necrosis.The Biochemical journal · 1996Article
- The expression of vimentin in satellite cells of regenerating skeletal muscle in vivo.The Histochemical journal · 1994Article
- CD24, a signal-transducing molecule expressed on human B lymphocytes, is a marker for human regenerating muscle.Acta neuropathologica · 1993Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We studied the fate of desmin and titin in rat skeletal muscle during a cycle of degeneration and regeneration induced in vivo by the inoculation of a snake venom. Cryosections of muscle were labelled using antibodies to the two proteins, and examined at fixed time points after venom injection. Early pathological changes in the muscle, such as hypercontraction, preceded the loss of desmin. Immunolabelling using anti-desmin antibodies showed that desmin bridges were still intact when adjacent myofibrils were no longer aligned. The results suggested that although the hydrolysis of desmin is not necessary for the hypercontraction of muscle fibres, it probably contributes to complete fibre breakdown. Titin, or at least the part which lies close to the M-line, remained intact longer than desmin, but was also hydrolysed prior to complete disintegration of the fibres. Both desmin and titin were re-expressed in the regenerating myotubes by 2 days after venom inoculation, and became well organised even before the myofibrils became aligned. We conclude that desmin and titin are involved in both establishing and maintaining the structural integrity of the muscle fibres.
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