ArticleVirchows Archiv. A, Pathological anatomy and histopathology1992
An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part II: Epitheliosis and ductal carcinoma in situ.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 93 citations in OpenAlex.
- Article
- Spatially correlated phenotyping reveals K5-positive luminal progenitor cells and p63-K5/14-positive stem cell-like cells in human breast epithelium.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Multicolor immunofluorescence reveals that p63- and/or K5-positive progenitor cells contribute to normal breast epithelium and usual ductal hyperplasia but not to low-grade intraepithelial neoplasia of the breast.Virchows Archiv : an international journal of pathology · 2017Observational
- Significance of immunohistochemistry in breast cancer.World journal of clinical oncology · 2014Review
- Progesterone decreases levels of the adhesion protein E-cadherin and promotes invasiveness of steroid receptor positive breast cancers.Hormones & cancer · 2013Article
- Clinico-Pathological Characteristics of Triple Negative and Non Triple Negative High Grade Breast Carcinomas with and Without Basal Marker (CK5/6 and EGFR) Expression at a Rural Tertiary Hospital in India.Breast cancer : basic and clinical research · 2012Article
- [Immunohistochemistry in breast pathology: differential diagnosis of epithelial breast lesions].Der Pathologe · 2009Article
- [Flat epithelial neoplasia and other columnar cell lesions of the breast].Der Pathologe · 2006Article
- [The significance of "normal tissue" in the development of breast cancer: new concepts of early carcinogenesis].Der Pathologe · 2006Article
- Preinvasive intraductal neoplasia in salivary adenocarcinoma, not otherwise specified.Virchows Archiv : an international journal of pathology · 2006Article
- CD44s is useful in the differentiation of benign and malignant papillary lesions of the breast.Journal of clinical pathology · 2005Article
- Axillary apocrine carcinoma with benign apocrine tumours: a case report involving a pathological and immunohistochemical study and review of the literature.Journal of clinical pathology · 2005Review
- Proteotypic classification of spontaneous and transgenic mammary neoplasms.Breast cancer research : BCR · 2004Article
- BRCA1 functions as a breast stem cell regulator.Journal of medical genetics · 2004Review
- Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell concept.Cell proliferation · 2003Review
- Value of cytokeratin 5/6 immunostaining using D5/16 B4 antibody in the spectrum of proliferative intraepithelial lesions of the breast. A comparative study with 34betaE12 antibody.Virchows Archiv : an international journal of pathology · 2003Article
- Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones.Endocrine-related cancer · 2000Review
- Immunolocalization and gene expression of oxytocin receptors in carcinomas and non-neoplastic tissues of the breast.The American journal of pathology · 1996Article
- Spectrum of carcinoembryonic antigen immunoreactivity from isolated ductal hyperplasias to atypical hyperplasias associated with infiltrating ductal breast cancer.Journal of clinical pathology · 1995Article
- Immunohistochemical demonstration of metallothionein in normal human breast tissue and benign and malignant breast lesions.Breast cancer research and treatment · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A detailed immunohistochemical study has been carried out on 63 breast lesions with epitheliosis, ductal carcinoma in situ and clinging carcinoma (lobular cancerization), using antibodies directed against keratins 5/14 and 14, 15, 16, 18, 19, vimentin, smooth muscle actin, collagen IV and laminin. The results have shown that epitheliosis on the one hand and ductal in situ and clinging carcinoma on the other are immunohistochemically different epithelial lesions. Epitheliosis appears to be epithelial hyperplasia with keratin 5/14 and keratin 14, 15, 16, 18, 19-positive cells. Compared to epitheliotic cells tumor cells of clinging carcinoma, lobular cancerization and ductal carcinoma in situ expressed only luminal keratins 14, 15, 16, 18, 19 in 85% of the cases studied; whereas in 15% there was a basal keratin expression. From our results we conclude that the clinging carcinoma (lobular cancerization) represents the initial morphological step in the development of ductal carcinoma in situ and thus may be interpreted as a minimal ductal neoplasia. With the immunohistochemical demonstration of basal and luminal keratins it may be possible in individual cases to differentiate between benign and malignant in situ lesions of the breast.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.