ArticleVirchows Archiv. A, Pathological anatomy and histopathology1992
An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part I: Normal breast and benign proliferative lesions.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 118 citations in OpenAlex.
- Transcriptional regulation of normal human mammary cell heterogeneity and its perturbation in breast cancer.The EMBO journal · 2019Review
- Spontaneous Mammary Adenocarcinoma in a Twelve-week-old Female Sprague-Dawley Rat.Journal of toxicologic pathology · 2012Article
- [Immunohistochemistry in breast pathology: differential diagnosis of epithelial breast lesions].Der Pathologe · 2009Article
- Understanding and treating triple-negative breast cancer.Oncology (Williston Park, N.Y.) · 2008Review
- The role of immunohistochemistry for smooth-muscle actin, p63, CD10 and cytokeratin 14 in the differential diagnosis of papillary lesions of the breast.Journal of clinical pathology · 2007Article
- Genome-scale identification of membrane-associated human mRNAs.PLoS genetics · 2006Article
- CD44s is useful in the differentiation of benign and malignant papillary lesions of the breast.Journal of clinical pathology · 2005Article
- Mutation of GATA3 in human breast tumors.Oncogene · 2004Article
- Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell concept.Cell proliferation · 2003Review
- Value of cytokeratin 5/6 immunostaining using D5/16 B4 antibody in the spectrum of proliferative intraepithelial lesions of the breast. A comparative study with 34betaE12 antibody.Virchows Archiv : an international journal of pathology · 2003Article
- A developmental atlas of rat mammary gland histology.Journal of mammary gland biology and neoplasia · 2000Review
- Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Immunolocalization and gene expression of oxytocin receptors in carcinomas and non-neoplastic tissues of the breast.The American journal of pathology · 1996Article
- Oxytocin inhibits proliferation of human breast cancer cell lines.Virchows Archiv : an international journal of pathology · 1994Article
- Immunohistochemical demonstration of metallothionein in normal human breast tissue and benign and malignant breast lesions.Breast cancer research and treatment · 1994Article
- An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part II: Epitheliosis and ductal carcinoma in situ.Virchows Archiv. A, Pathological anatomy and histopathology · 1992Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution of simple epithelial (K8/18/19) and basal (myoepithelial) (K5/14) keratins, alpha-smooth-muscle actin, vimentin, collagen IV and laminin in normal mammary glands and in benign proliferative lesions was studied using monoclonal antibodies (mAbs). These antibodies (Abs) identified myoepithelial cells and luminal cells specifically. In lesions with adenosis and papillomas, the two-layered formation resembled that of normal glands with a purely myoepithelial-epithelial differentiation. In scleradenotic lesions, the main cell was of myoepithelial immunophenotype with intermixed trabecular-tubular proliferations of simple-type epithelium. The sclerosis seems to be the result of an irregular basal lamina synthesis by the myoepithelial cells. In contrast to these lesions, epitheliosis represents a purely intraluminal cell proliferation of clearly simple epithelial immunophenotype and of cells with a basal keratin phenotype, lacking myoepithelial differentiation antigen actin. The basal keratin type epithelium may represent post-stem or intermediate cells developing into luminal epithelium. Epitheliosis appears to be a purely epithelial hyperplasia with striking similarity to the regeneration of normal breast epithelium. The different proliferative patterns may give an explanation for differences in potential cancer risks of patients with these lesions.
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