ArticleProceedings of the National Academy of Sciences of the United States of America1992
Evidence that the deep keratin filament systems of the Xenopus embryo act to ensure normal gastrulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 68 citations in OpenAlex.
- Article
- 14-3-3 targets keratin intermediate filaments to mechanically sensitive cell-cell contacts.Molecular biology of the cell · 2020Article
- Desmoplakin is required for epidermal integrity and morphogenesis in the Xenopus laevis embryo.Developmental biology · 2019Article
- Filaments and phenotypes: cellular roles and orphan effects associated with mutations in cytoplasmic intermediate filament proteins.F1000Research · 2019Review
- Mechanical and signaling roles for keratin intermediate filaments in the assembly and morphogenesis ofDevelopment (Cambridge, England) · 2017Article
- Intermediate Filaments at the Junction of Mechanotransduction, Migration, and Development.Frontiers in cell and developmental biology · 2017Review
- Article
- A mechanoresponsive cadherin-keratin complex directs polarized protrusive behavior and collective cell migration.Developmental cell · 2012Article
- Evidence for partial epithelial-to-mesenchymal transition (pEMT) and recruitment of motile blastoderm edge cells during avian epiboly.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Intermediate filaments as dynamic structures.Cancer metastasis reviews · 1996Review
- Oncogenic regulation and function of keratins 8 and 18.Cancer metastasis reviews · 1996Review
- Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly.The Journal of cell biology · 1996Article
- E5 oncoprotein transmembrane mutants dissociate fibroblast transforming activity from 16-kilodalton protein binding and platelet-derived growth factor receptor binding and phosphorylation.Journal of virology · 1996Article
- E5 oncoprotein retained in the endoplasmic reticulum/cis Golgi still induces PDGF receptor autophosphorylation but does not transform cells.The EMBO journal · 1995Article
- Anterior axis duplication in Xenopus induced by the over-expression of the cadherin-binding protein plakoglobin.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Determinants for intracellular sorting of cytoplasmic and nuclear intermediate filaments.The Journal of cell biology · 1994Article
- Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization.The Journal of cell biology · 1994Article
- Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin.The Journal of cell biology · 1994Article
- Mutation of the bovine papillomavirus E5 oncoprotein at amino acid 17 generates both high- and low-transforming variants.Journal of virology · 1994Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study the role of keratin filaments in Xenopus development, fertilized eggs were injected with anti-keratin monoclonal antibodies. The anti-keratin monoclonal antibodies AE1 and AE3 induce abnormal gastrulation; in the most severely affected embryos gastrulation fails completely. In contrast, embryos injected with the anti-keratin antibody 1h5 develop normally. Immunocytochemical data indicate that injected 1h5 binds to the dense superficial keratin filament system of the embryo but not to the deeper keratin filament networks of ectodermal and subectodermal cells. Injected AE1 and AE3 do not bind to the superficial keratin system but appear to interact preferentially with the deep keratin filament systems of the embryo. We conclude that the superficial keratin filament system is not involved in the process of gastrulation per se but may protect the embryo from mechanical damage. On the other hand, our results suggest that the integrity of the deeper keratin filament systems is required for the mechanical integration of the morphogenetic movements that underlie gastrulation in Xenopus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.