ArticlePflugers Archiv : European journal of physiology1992
Calcium-dependence of the calcium-activated chloride current in smooth muscle cells of rat portal vein.
Article in Pflugers Archiv : European journal of physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 66 citations in OpenAlex.
- Intraluminal pressure triggers myogenic response via activation of calcium spark and calcium-activated chloride channel in rat renal afferent arteriole.American journal of physiology. Renal physiology · 2018Article
- Cellular functions of TMEM16/anoctamin.Pflugers Archiv : European journal of physiology · 2016Review
- TMEM16A knockdown abrogates two different Ca(2+)-activated Cl (-) currents and contractility of smooth muscle in rat mesenteric small arteries.Pflugers Archiv : European journal of physiology · 2014Article
- Cl⁻ channels in smooth muscle cells.Pflugers Archiv : European journal of physiology · 2014Review
- Role of ROS signaling in differential hypoxic Ca2+ and contractile responses in pulmonary and systemic vascular smooth muscle cells.Respiratory physiology & neurobiology · 2010Article
- A close association of RyRs with highly dense clusters of Ca2+-activated Cl- channels underlies the activation of STICs by Ca2+ sparks in mouse airway smooth muscle.The Journal of general physiology · 2008Article
- A cyclic GMP-dependent calcium-activated chloride current in smooth-muscle cells from rat mesenteric resistance arteries.The Journal of general physiology · 2004Article
- Modulation of Ca2+-dependent Cl- channels by calcineurin in rabbit coronary arterial myocytes.The Journal of physiology · 2003Article
- Comparison of the properties of CLCA1 generated currents and I(Cl(Ca)) in murine portal vein smooth muscle cells.The Journal of physiology · 2002Article
- Cell-to-cell communication via nitric oxide modulation of oscillatory Cl(-) currents in rat intact cerebral arterioles.The Journal of physiology · 2001Article
- Differential regulation of Ca(2+)-activated Cl(-) currents in rabbit arterial and portal vein smooth muscle cells by Ca(2+)-calmodulin-dependent kinase.The Journal of physiology · 2001Article
- Nifedipine blocks Ca2+ store refilling through a pathway not involving L-type Ca2+ channels in rabbit arteriolar smooth muscle.The Journal of physiology · 2001Article
- Ca2+ sparks activate K+ and Cl- channels, resulting in spontaneous transient currents in guinea-pig tracheal myocytes.The Journal of physiology · 1998Article
- Inactivation of calcium-activated chloride channels in smooth muscle by calcium/calmodulin-dependent protein kinase.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Modulation of Ca(2+)-activated Cl- currents in rabbit portal vein smooth muscle by an inhibitor of mitochondrial Ca2+ uptake.The Journal of physiology · 1997Article
- Analysis of the time course of calcium-activated chloride "tail" currents in rabbit portal vein smooth muscle cells.Pflugers Archiv : European journal of physiology · 1996Article
- Release of Ca2+ from intracellular store in smooth muscle cells of rat portal vein by ATP-induced Ca2+ entry.British journal of pharmacology · 1994Article
- Photoreleased inositol 1,4,5-trisphosphate-induced response in single smooth muscle cells of rat portal vein.The Journal of physiology · 1994Article
- ATP-sensitive K+ channel opener acts as a potent Cl- channel inhibitor in vascular smooth muscle cells.The Journal of membrane biology · 1994Article
- Endothelin and vasopressin activate low conductance chloride channels in aortic smooth muscle cells.Pflugers Archiv : European journal of physiology · 1993Article
Corrections and comments
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Authors and funding
5 authors at 1 institution.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ca(2+)-activated Cl- current in freshly isolated smooth muscle cells from rat portal vein was studied using the whole-cell patch-clamp technique. Simultaneously, the free-cytosolic Ca2+ concentration (Cai) was estimated using emission from the dye Indo-1. Pretreatment of the cells with amytal and carbonyl-cyanide-m-chlorophenylhydrazone, which reduced the intracellular adenosine triphosphate concentration, was used to weaken the cellular Ca2+ homeostatic system. Cai of treated cells slowly increased during perfusion with an external Ca(2+)-containing solution. This rise in Cai gradually activated a Ca(2+)-dependent Cl- current which allowed the study of the relationship between activation of this current and Cai levels. The threshold Cai for activation of Cl- channels was around 180 nM and full activation occurred at 600 nM. The Cai dependence of the Cl- channels was not changed during application of noradrenaline and did not depend on the membrane potential. The gating of Ca(2+)-dependent Cl- channels of rat portal vein myocytes seems to be mainly controlled by intracellular Ca2+.
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