ArticleJournal of virology1992
Wild-type equine infectious anemia virus replicates in vivo predominantly in tissue macrophages, not in peripheral blood monocytes.
Article in Journal of virology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
43 citing papers in PubMed, 114 citations in OpenAlex.
- Host cell restriction factors of equine infectious anemia virus.Virologica Sinica · 2023Review
- Delivery strategies for CRISPR/Cas genome editing tool for retinal dystrophies: challenges and opportunities.Asian journal of pharmaceutical sciences · 2022Review
- Equine lentivirus counteracts SAMHD1 restriction by Rev-mediated degradation of SAMHD1 via the BECN1-dependent lysosomal pathway.Autophagy · 2021Article
- Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hosts.The Journal of biological chemistry · 2018Article
- Gene therapy and genome surgery in the retina.The Journal of clinical investigation · 2018Review
- Infection with equine infectious anemia virus vaccine strain EIAVDLV121 causes no visible histopathological lesions in target organs in association with restricted viral replication and unique cytokine response.Veterinary immunology and immunopathology · 2016Article
- Mice transgenic for equine cyclin T1 and ELR1 are susceptible to equine infectious anemia virus infection.Retrovirology · 2015Article
- Equine viperin restricts equine infectious anemia virus replication by inhibiting the production and/or release of viral Gag, Env, and receptor via distortion of the endoplasmic reticulum.Journal of virology · 2014Article
- Interstitial lung disease associated with Equine Infectious Anemia Virus infection in horses.Veterinary research · 2013Article
- Transduction of photoreceptors with equine infectious anemia virus lentiviral vectors: safety and biodistribution of StarGen for Stargardt disease.Investigative ophthalmology & visual science · 2013Article
- Unique evolution characteristics of the envelope protein of EIAV(LN₄₀), a virulent strain of equine infectious anemia virus.Virus genes · 2011Article
- The inside out of lentiviral vectors.Viruses · 2011Review
- Restriction of equine infectious anemia virus by equine APOBEC3 cytidine deaminases.Journal of virology · 2009Article
- Equine infectious anemia virus resists the antiretroviral activity of equine APOBEC3 proteins through a packaging-independent mechanism.Journal of virology · 2008Article
- An equine infectious anemia virus variant superinfects cells through novel receptor interactions.Journal of virology · 2008Article
- Development and characterization of an equine infectious anemia virus Env-pseudotyped reporter virus.Clinical and vaccine immunology : CVI · 2008Article
- Equine infectious anemia virus entry occurs through clathrin-mediated endocytosis.Journal of virology · 2008Article
- Although macrophage-tropic simian/human immunodeficiency viruses can exhibit a range of pathogenic phenotypes, a majority of isolates induce no clinical disease in immunocompetent macaques.Journal of virology · 2007Article
- Human immunodeficiency virus bearing a disrupted central DNA flap is pathogenic in vivo.Journal of virology · 2007Review
- HIV infection of non-dividing cells: a divisive problem.Retrovirology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In situ hybridization of tissues from two horses infected with the wild-type Wyoming strain of equine infectious anemia virus (EIAV) identified the liver, spleen, lymph nodes, kidney, lung, and adrenal gland as the primary host tissue sites for viral transcription during acute infection. Combined immunohistochemistry, with a monoclonal antibody recognizing a cytoplasmic antigen of equine mononuclear phagocytes, and in situ hybridization for viral RNA identified most infected cells as mature tissue macrophages. In contrast, in situ hybridization of adherent peripheral blood mononuclear cells collected from horses on various days during the first 2 weeks postinfection with the Wyoming strain of EIAV failed to detect any viral RNA in these cells. For the two horses described here, serum reverse transcriptase activity correlated directly with the degree of replication detected in tissue macrophages on the day of sacrifice. These results suggest that unlike other lentivirus infections in which mature tissue macrophages accumulate cytoplasmic viral RNA to a high level but fail to produce infectious virions, mature tissue macrophages are the likely primary source of the high titer of viremia present during acute infection with EIAV. No significant posttranscriptional block of viral replication in tissue macrophages appears to occur with EIAV.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.