ArticleProceedings of the National Academy of Sciences of the United States of America1992
Increased tyrosine kinase activity of c-Src during calcium-induced keratinocyte differentiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 106 citations in OpenAlex.
- Dysregulation of STS in keratinocytes promotes calcium signaling and differentiation.Scientific reports · 2025Article
- GKT137831 and hydrogen peroxide increase the release of 6-nitrodopamine from the human umbilical artery, rat-isolated right atrium, and rat-isolated vas deferens.Frontiers in pharmacology · 2024Article
- Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein.Pathogens (Basel, Switzerland) · 2021Review
- Lung Endothelial Transcytosis.Comprehensive Physiology · 2020Review
- Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Resistin, a fat-derived secretory factor, promotes metastasis of MDA-MB-231 human breast cancer cells through ERM activation.Scientific reports · 2016Article
- Src kinases regulate de novo actin polymerization during exocytosis in neuroendocrine chromaffin cells.PloS one · 2014Article
- The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation.The Journal of biological chemistry · 2012Article
- c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes.The international journal of biochemistry & cell biology · 2011Article
- Tyrosine phosphorylation of nuclear-membrane protein emerin by Src, Abl and other kinases.Journal of cell science · 2009Article
- Expression, localisation and functional activation of NFAT-2 in normal human skin, psoriasis, and cultured keratocytes.International journal of clinical and experimental medicine · 2009Article
- Expression of N-terminal truncated desmoglein 3 (deltaNDg3) in epidermis and its role in keratinocyte differentiation.Experimental & molecular medicine · 2009Article
- mda-9/Syntenin promotes metastasis in human melanoma cells by activating c-Src.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Regulation of p73 by Hck through kinase-dependent and independent mechanisms.BMC molecular biology · 2007Article
- Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1.Molecular biology of the cell · 2005Article
- Laminin-sulfatide binding initiates basement membrane assembly and enables receptor signaling in Schwann cells and fibroblasts.The Journal of cell biology · 2005Article
- Expression of ryanodine receptors in human embryonic kidney (HEK293) cells.The Biochemical journal · 1998Article
- Expression of voltage-gated potassium channels decreases cellular protein tyrosine phosphorylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Role of cell-cell adhesion in the regulation of prolactin gene expression by extracellular CaCl(2).Endocrine · 1996Article
- Voltage-insensitive Ca2+ channels and Ca2+/calmodulin-dependent protein kinases propagate signals from endothelin-1 receptors to the c-fos promoter.Molecular and cellular biology · 1996Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In cultured human epidermal keratinocytes, induction of differentiation by Ca2+ and ionophore treatment was found to result in rapid elevation of c-Src tyrosine kinase activity and inactivation of the c-Yes tyrosine kinase. Activation of c-Src kinase was accompanied by tyrosine dephosphorylation, which might be explained by a rapid increase in intracellular protein-tyrosine phosphatase activity. Ca(2+)-induced differentiation was also associated with altered tyrosine phosphorylation of several cellular proteins and correlated with a marked redistribution of intracellular phosphotyrosine from membrane and adhesion sites to the nucleus. Some of the c-Src protein was also found in the nucleus after Ca2+ treatment, and Ca(2+)-activated c-Src bound to three cellular proteins (120 kDa, 65 kDa, and 34 kDa). In agreement with these results, immunohistochemistry on human epidermis revealed an increase in c-Src expression and tyrosine phosphorylation in cells undergoing differentiation, which strongly suggests a possible role of non-receptor tyrosine kinases in epithelial cell maturation.
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