ArticleVirchows Archiv. A, Pathological anatomy and histopathology1992
Changes in cytokeratin expression accompany squamous metaplasia of the human respiratory epithelium.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 45 citations in OpenAlex.
- Characterization of epithelial cells, connective tissue cells and immune cells in human upper airway mucosa by immunofluorescence multichannel image cytometry: a pilot study.Histochemistry and cell biology · 2021Article
- Expression of C4.4A in an In Vitro Human Tissue-Engineered Skin Model.BioMed research international · 2017Article
- SuperSILAC Quantitative Proteome Profiling of Murine Middle Ear Epithelial Cell Remodeling with NTHi.PloS one · 2016Article
- SOX1 down-regulates β-catenin and reverses malignant phenotype in nasopharyngeal carcinoma.Molecular cancer · 2014Article
- C4.4A as a biomarker in pulmonary adenocarcinoma and squamous cell carcinoma.World journal of clinical oncology · 2014Review
- Growth and differentiation of primary and passaged equine bronchial epithelial cells under conventional and air-liquid-interface culture conditions.BMC veterinary research · 2011Article
- The human keratins: biology and pathology.Histochemistry and cell biology · 2008Review
- Cable pili and the 22-kilodalton adhesin are required for Burkholderia cenocepacia binding to and transmigration across the squamous epithelium.Infection and immunity · 2005Article
- Changes in the gene expression pattern of cytokeratins in human respiratory epithelial cells during culture.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2005Article
- Nuclear heat shock response and novel nuclear domain 10 reorganization in respiratory syncytial virus-infected a549 cells identified by high-resolution two-dimensional gel electrophoresis.Journal of virology · 2004Article
- HPV infections and lung cancer.Journal of clinical pathology · 2002Review
- Cable-piliated Burkholderia cepacia binds to cytokeratin 13 of epithelial cells.Infection and immunity · 2000Article
- Staphylococcus aureus adherence to nasal epithelial cells in a physiological in vitro model.In vitro cellular & developmental biology. Animal · 1999Article
- Immunohistochemical examination of 11 cell lines derived from human head and neck squamous cell carcinomas, their recurrences or metastases.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 1995Article
- Extracellular matrix-dependent differentiation of rabbit tracheal epithelial cells in primary culture.In vitro cellular & developmental biology. Animal · 1994Article
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3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine the characteristics of metaplastic changes of the nasal respiratory epithelium, the distribution of individual cytokeratins (CKs) was studied immunohistochemically and by two-dimensional gel electrophoresis. The authors define four types of changes of the normal pseudostratified columnar epithelium: (1) transitional pseudostratified epithelium (first unusual CK.: no. 13); (2) stratified columnar epithelium (increased expression of CKs 4 and 13; CKs 7, 8, 18 and 19 reduced); (3) stratified squamous epithelium, nonkeratinized (appearance of CK 16); and (4) stratified squamous epithelium, keratinized (expression of CKs 1 and 10, variable CK5 and 14 patterns in basal cells). These phenotypes were found simultaneously within single specimens, resulting in apparent overall variability in the immunohistochemical staining patterns. Spatially, changes in CK expression towards "normal" parts were not abrupt but rather gradual. Biochemical data confirmed the immunohistochemical findings and added CK 6 to the pattern of altered nasal mucosa. The findings of this study suggest a stem cell metaplasia in the nasal epithelium which is based on its inherent bimodal developmental programme. A gradual loss of normal respiratory epithelial differentiation, as seen by the loss of CKs 7, 8, and 18, was paralleled by the appearance of squamous epithelial type CKs, e.g. the expression of CKs 1, 10 and 13. Basal cell types CKs 5, 14, 17 and 19 were maintained during this process. Implications of these results for general concepts of CK expression in the metaplastic process are discussed.
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