ArticleThe Journal of experimental medicine1992
The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2+ oscillations.
Article in The Journal of experimental medicine, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 78 citations in OpenAlex.
- Selective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Protein tyrosine phosphatases and the immune response.Nature reviews. Immunology · 2005Review
- Positive and negative regulation of T-cell activation through kinases and phosphatases.The Biochemical journal · 2003Review
- Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor.Molecular and cellular biology · 2003Article
- A stable aberrant immunophenotype characterizes nearly all cases of cutaneous T-cell lymphoma in blood and can be used to monitor response to therapy.BMC clinical pathology · 2002Article
- CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Regulation of cell signaling by the protein tyrosine phosphatases, CD45 and SHP-1.Immunologic research · 1997Review
- The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.The EMBO journal · 1996Article
- Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity.Molecular and cellular biology · 1996Article
- The unique amino-terminal domain of p56lck regulates interactions with tyrosine protein phosphatases in T lymphocytes.Molecular and cellular biology · 1995Article
- Developmental regulation of TCR-CD3-dependent [Ca2+]i responses of individual normal and pp59fyn-deficient T lymphocytes.Immunology · 1995Article
- CD45 tyrosine phosphatase activity and membrane anchoring are required for T-cell antigen receptor signaling.Molecular and cellular biology · 1994Article
- Surface expression of a heterologous phosphatase complements CD45 deficiency in a T cell clone.The Journal of experimental medicine · 1994Article
- IFN-gamma abrogates IL-7-dependent proliferation in pre-B cells, coinciding with onset of apoptosis.Immunology · 1994Article
- Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase.Molecular and cellular biology · 1994Article
- Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD45 is a transmembrane tyrosine phosphatase implicated in T cell antigen receptor (TCR)-mediated activation. In T cell variants expressing progressively lower levels of CD45 (from normal to undetectable), CD45 expression was inversely related to spontaneous tyrosine phosphorylation of multiple proteins, including the TCR zeta chain, and was directly correlated with TCR-driven phosphoinositide hydrolysis. The Ca2+ response in these cells was altered in an unexpected fashion. Unlike wild-type cells, stimulated CD45- cell populations did not manifest an early increase in intracellular Ca2+, but did exhibit a delayed and gradual increase in mean intracellular Ca2+. Computer-aided fluorescence imaging of individual cells revealed that CD45- cells experienced late Ca2+ oscillations that were not blocked by removal of extracellular Ca2+. CD45 revertants had the signaling properties of wild-type cells. Thus, CD45 has a profound influence on both TCR-mediated signaling and phosphotyrosine homeostasis, and its loss reveals a novel role for this tyrosine phosphatase in Ca2+ regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.