ReviewJournal of bioenergetics and biomembranes1992
Modulation of inner mitochondrial membrane channel activity.
Review in Journal of bioenergetics and biomembranes, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Identification and Ultrastructural Peculiarities of Nestin-Carrying Progenitor Cells in Kidney.International journal of molecular sciences · 2026Article
- Investigation of mitochondrial inner membrane ion conductance by planar lipid bilayer electrophysiology.Frontiers in physiology · 2026Article
- Mitochondrial ATP synthase c-subunit leak channel triggers cell death upon loss of its FCell death and differentiation · 2022Article
- Mitochondrial ion channels in cardiac function.American journal of physiology. Cell physiology · 2021Review
- Butyrate Feeding Reverses CypD-Related Mitoflash Phenotypes in Mouse Myofibers.International journal of molecular sciences · 2021Article
- Electrophysiological properties of the mitochondrial permeability transition pores: Channel diversity and disease implication.Biochimica et biophysica acta. Bioenergetics · 2021Review
- The very low number of calcium-induced permeability transition pores in the single mitochondrion.The Journal of general physiology · 2020Article
- Physiological CaFrontiers in physiology · 2020Review
- A mitochondrial megachannel resides in monomeric FNature communications · 2019Article
- ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore.Cell reports · 2019Article
- Anion Channels of Mitochondria.Handbook of experimental pharmacology · 2017Review
- Mitochondrial chloride channels: electrophysiological characterization and pH induction of channel pore dilation.European biophysics journal : EBJ · 2013Article
- Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress.Journal of molecular and cellular cardiology · 2011Article
- Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels.FEBS letters · 2010Review
- Mitochondrial ion channels.Annual review of physiology · 2007Review
- A large, voltage-dependent channel, isolated from mitochondria by water-free chloroform extraction.Biophysical journal · 2005Article
- Comparison of the TIM and TOM channel activities of the mitochondrial protein import complexes.Biophysical journal · 2003Article
- MCC and PSC, the putative protein import channels of mitochondria.Journal of bioenergetics and biomembranes · 2000Review
- Oscillating Ca2+-induced channel activity obtained in BLM with a mitochondrial membrane component.Journal of bioenergetics and biomembranes · 1997Article
- Effects of carbonyl cyanide phenylhydrazones on two mitochondrial ion channel activities.Journal of bioenergetics and biomembranes · 1997Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three classes of inner mitochondrial membrane (IMM) channel activities have been defined by direct measurement of conductance levels in membranes with patch clamp techniques in 150 mM KCl. The "107 pS activity" is slightly anion selective and voltage dependent (open with matrix positive potentials). "Multiple conductance channel" (MCC) activity includes several levels from about 40 to over 1000 pS and can be activated by voltage or Ca2+. MCC may be responsible for the Ca(2+)-induced permeability transition observed with mitochondrial suspensions. A "low conductance channel" (LCC) is activated by alkaline pH and inhibited by Mg2+. LCC has a unit conductance of about 15 pS and may correspond to the inner membrane anion channel, IMAC, which was proposed from the results obtained from suspension studies. All of the IMM channels defined thus far appear to be highly regulated and have a low open probability under physiological conditions. A summary of what is known about IMM channel regulation and pharmacology is presented and possible physiological roles of these channels are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.