ArticleProceedings of the National Academy of Sciences of the United States of America1992
A high-molecular-weight squid neurofilament protein contains a lamin-like rod domain and a tail domain with Lys-Ser-Pro repeats.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 65 citations in OpenAlex.
- Neural pathways in the pallial nerve and arm nerve cord revealed by neurobiotin backfilling in the cephalopod mollusk Octopus vulgaris.Invertebrate neuroscience : IN · 2019Article
- Hibernation induces changes in the metacerebral neurons of Cornu aspersum: distribution and co-localization of cytoskeletal and calcium-binding proteins.Invertebrate neuroscience : IN · 2018Article
- Squid Giant Axons Synthesize NF Proteins.Molecular neurobiology · 2018Article
- Squid Giant Axon Contains Neurofilament Protein mRNA but does not Synthesize Neurofilament Proteins.Cellular and molecular neurobiology · 2017Article
- Axonal maintenance, glia, exosomes, and heat shock proteins.F1000Research · 2016Review
- Multiple neurofilament subunits are present in lamprey CNS.Brain research · 2011Article
- Requirement of heavy neurofilament subunit in the development of axons with large calibers.The Journal of cell biology · 1998Article
- Active polysomes are present in the large presynaptic endings of the synaptosomal fraction from squid brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Phosphorylation and subunit organization of axonal neurofilaments determined by scanning transmission electron microscopy.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Characterization of squid enolase mRNA: sequence analysis, tissue distribution, and axonal localization.Neurochemical research · 1995Article
- Determinants for intracellular sorting of cytoplasmic and nuclear intermediate filaments.The Journal of cell biology · 1994Article
- Eight genes and alternative RNA processing pathways generate an unexpectedly large diversity of cytoplasmic intermediate filament proteins in the nematode Caenorhabditis elegans.The EMBO journal · 1994Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown that two low molecular-weight neurofilament (NF) proteins (NF-60 and NF-70) from the squid Loligo pealei are translated from mRNAs that are splice variants of a single squid NF gene. In this study, we report the isolation and characterization of cDNA clones encoding a high-molecular-weight squid NF protein (NF-220), the mRNA of which derives from the same squid NF gene. All three proteins are identical in their amino-terminal and lamin-like rod domains but differ in their carboxyl-terminal tail regions. In contrast to the short tail domains of NF-60 and NF-70, the NF-220 protein has a longer tail domain containing an acidic cluster of amino acids immediately followed by repeated copies of the sequence motif Lys-Ser-Pro. The Lys-Ser-Pro domain is similar to that of mammalian medium NF (NF-M) and high NF (NF-H) proteins, where the serines are highly phosphorylated. Except for these Lys-Ser-Pro motifs, there is surprisingly little structural similarity between the squid NF-220 protein and mammalian NF-M and NF-H proteins. Furthermore, the location of introns in squid NF-220 protein shows that it is more closely related to nuclear lamins and type III intermediate-filament proteins than to vertebrate NF proteins.
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