ArticleThe Journal of clinical investigation1992
Polymerase chain reaction localization of constitutive nitric oxide synthase and soluble guanylate cyclase messenger RNAs in microdissected rat nephron segments.
Article in The Journal of clinical investigation, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 245 citations in OpenAlex.
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- Renal cell markers: lighthouses for managing renal diseases.American journal of physiology. Renal physiology · 2021Article
- Renal Soluble Guanylate Cyclase Is Downregulated in Sunitinib-Induced Hypertension.Journal of the American Heart Association · 2018Article
- Effects of Nitric Oxide on Renal Proximal Tubular NaBioMed research international · 2017Review
- Blood pressure, sex, and female sex hormones influence renal inner medullary nitric oxide synthase activity and expression in spontaneously hypertensive rats.Journal of the American Heart Association · 2015Article
- Angiotensin II type 2 receptor regulates ROMK-like K⁺ channel activity in the renal cortical collecting duct during high dietary K⁺ adaptation.American journal of physiology. Renal physiology · 2014Article
- Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity.American journal of physiology. Renal physiology · 2014Article
- Telmisartan protects 5/6 Nx rats against renal injury by enhancing nNOS-derived NO generation via regulation of PPARγ signaling.American journal of translational research · 2014Article
- Angiotensin II regulates NOS expression in afferent arterioles of the developing porcine kidney.Pediatric research · 2010Article
- Nitric oxide produced by endothelial nitric oxide synthase promotes diuresis.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Renal proximal tubular reabsorption is reduced in adult spontaneously hypertensive rats: roles of superoxide and Na+/H+ exchanger 3.Hypertension (Dallas, Tex. : 1979) · 2009Article
- Nitric oxide decreases expression of osmoprotective genes via direct inhibition of TonEBP transcriptional activity.Pflugers Archiv : European journal of physiology · 2009Article
- Nitric oxide synthase and renin-angiotensin gene expression and NOS function in the postnatal renal resistance vasculature.Pediatric nephrology (Berlin, Germany) · 2009Article
- The effect of L-arginine methyl ester on indices of free radical involvement in a rat model of experimental nephrocalcinosis.Urological research · 2006Article
- Nitric oxide synthesis in the adult and developing kidney.Electrolyte & blood pressure : E & BP · 2006Review
- Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells.The Journal of clinical investigation · 2000Article
- Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor.Molecular and cellular biology · 2000Article
- Atrial natriuretic peptide and oxytocin induce natriuresis by release of cGMP.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Altered renal expression of nitric oxide synthase isozymes in spontaneously hypertensive rats.The Korean journal of internal medicine · 1999Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stimulation of the release of nitric oxide (NO) in the kidney has been shown to result in renal hemodynamic changes and natriuresis. NO is a potent stimulator of soluble guanylate cyclase, leading to an increase of cyclic GMP. The precise localization of NO synthase and soluble guanylate cyclase in the renal structure is not known. In this study, the microlocalization of mRNAs coding for constitutive NO synthase and soluble guanylate cyclase was carried out in the rat kidney, using an assay of reverse transcription and polymerase chain reaction in individual microdissected renal tubule segments along the nephron, glomeruli, vasa recta bundle, and arcuate arteries. A large signal for constitutive NO synthase was detected in inner medullary collecting duct. Small signals were detected in inner medullary thin limb, cortical collecting duct, outer medullary collecting duct, glomerulus, vasa recta, and arcuate artery. Soluble guanylate cyclase mRNA is expressed largely in glomerulus, proximal convoluted tubule, proximal straight tubule, and cortical collecting duct, and in small amounts in medullary thick ascending limb, inner medullary thin limb, outer medullary collecting duct, inner medullary collecting duct, and the vascular system. Our data demonstrate that NO can be produced locally in the kidney, and that soluble guanylate cyclase is widely distributed in glomerulus, renal tubules, and the vascular system.
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