ArticleThe Journal of cell biology1992
Direct activation of second messenger pathways mimics cell adhesion molecule-dependent neurite outgrowth.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 94 citations in OpenAlex.
- Review
- Intracellular signaling by the neural cell adhesion molecule.Neurochemical research · 2003Review
- Abnormal targeting of developing hippocampal mossy fibers after epileptiform activities via L-type Ca2+ channel activation in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Intracellular signaling is changed after clustering of the neural cell adhesion molecules axonin-1 and NgCAM during neurite fasciculation.The Journal of cell biology · 1996Article
- Gonadal steroids and astroglial plasticity.Cellular and molecular neurobiology · 1996Review
- Stimulation of neurite outgrowth in PC12 cells by EGF and KCl depolarization: a Ca(2+)-independent phenomenon.The Journal of cell biology · 1995Article
- Neural cell adhesion molecule (NCAM) as a quantitative marker in synaptic remodeling.Neurochemical research · 1995Review
- Ca2+ influx and neurite growth in response to purified N-cadherin and laminin.The Journal of cell biology · 1994Article
- Unraveling the cytoplasmic interactions of the cadherin superfamily.Proceedings of the National Academy of Sciences of the United States of America · 1994Review
- NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice.The Journal of cell biology · 1994Article
- Current status of meningococcal group B vaccine candidates: capsular or noncapsular?Clinical microbiology reviews · 1994Review
- Expression of NCAM containing VASE in neurons can account for a developmental loss in their neurite outgrowth response to NCAM in a cellular substratum.The Journal of cell biology · 1994Article
- Tyrosine kinase inhibitors can differentially inhibit integrin-dependent and CAM-stimulated neurite outgrowth.The Journal of cell biology · 1994Article
- Integrin-mediated neurite outgrowth in neuroblastoma cells depends on the activation of potassium channels.The Journal of cell biology · 1993Article
- Thy-1 antibody-triggered neurite outgrowth requires an influx of calcium into neurons via N- and L-type calcium channels.The Journal of cell biology · 1993Article
- Calcium influx into neurons can solely account for cell contact-dependent neurite outgrowth stimulated by transfected L1.The Journal of cell biology · 1992Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We present evidence that direct activation of neuronal second messenger pathways in PC12 cells by opening voltage-dependent calcium channels mimics cell adhesion molecule (CAM)-induced differentiation of these cells. PC12 cells were cultured on monolayers of control 3T3 cells or 3T3 cells expressing transfected N-cadherin in the presence of KCl or a calcium channel agonist Bay K 8644. Both potassium depolarization and agonist-induced activation of calcium channels promoted substantial neurite outgrowth from PC12 cells cultured on control 3T3 monolayers and increased neurite outgrowth from those cultured on N-cadherin-expressing 3T3 monolayers. The potassium-induced response could be inhibited by L- and N-type calcium channel antagonists and by kinase inhibitor K-252b but was unaffected by pertussis toxin. In contrast activators of protein kinase C did not stimulate neurite outgrowth, and the neurite outgrowth response induced by activation of protein kinase A was not inhibited by calcium channel antagonists or pertussis toxin. These studies support the postulate that CAM-induced neuronal differentiation involves a specific transmembrane signaling pathway and suggest that activation of this pathway after CAM binding may be more important for the neurite outgrowth response than CAM-dependent adhesion per se.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.