ArticleProceedings of the National Academy of Sciences of the United States of America1992
Directed establishment of rat brain cell lines with the phenotypic characteristics of type 1 astrocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 89 citations in OpenAlex.
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- Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model.Cell death & disease · 2019Article
- Towards an advanced cell-basedAIMS genetics · 2018Review
- Oxabicycloheptene Sulfonate Protects Against β-Amyloid-induced Toxicity by Activation of PI3K/Akt and ERK Signaling Pathways Via GPER1 in C6 Cells.Neurochemical research · 2017Article
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- Acute and chronic mu opioids differentially regulate thrombospondins 1 and 2 isoforms in astrocytes.ACS chemical neuroscience · 2014Article
- A comparative study of protein carbonylation and mitochondrial dysfunction using the neurotoxicants 1,3-dinitrobenzene, 3-nitropropionic acid, and 3-chloropropanediol.Neurotoxicology · 2013Article
- Anti-proliferative effects of tricyclodecan-9-yl-xanthogenate (D609) involve ceramide and cell cycle inhibition.Molecular neurobiology · 2012Article
- Dendritic cells lower the permeability of endothelial monolayers.Cellular and molecular bioengineering · 2012Article
- Proteomic identification of carbonylated proteins in 1,3-dinitrobenzene neurotoxicity.Neurotoxicology · 2011Article
- Inhibition of reactive gliosis attenuates excitotoxicity-mediated death of retinal ganglion cells.PloS one · 2011Article
- An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formation.The Journal of biological chemistry · 2010Article
- Glial cell lines: an overview.Neurochemical research · 2010Review
- Automated cell-based assay for screening of aquaporin inhibitors.Analytical chemistry · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Interest in obtaining cell lines for use in studies on the development and biochemistry of the central nervous system has motivated efforts to establish cells from primary brain cultures by the use of oncogene-transfer techniques. In previous reports, cell lines derived from astrocytes in this way have had immature or abnormal phenotypes. We have explored the possibility of specifically "targeting" expression of exogenous oncogenes to differentiated astrocytes by using the promoter of the gene encoding glial fibrillary acidic protein, which is expressed almost exclusively in such cells. We report here that cell lines displaying the phenotypic characteristics of type 1 astrocytes can be established reproducibly in this manner. Given the heterogeneity of primary cultures, the availability of clonal cell lines displaying characteristics of type 1 astrocytes should greatly facilitate our understanding of the biology of these cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.