ArticleThe Journal of cell biology1992
Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDM1 protein.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 95 citations in OpenAlex.
- Characteristics of a Regulator of G-Protein Signaling (RGS)Frontiers in microbiology · 2017Article
- Mdm1/Snx13 is a novel ER-endolysosomal interorganelle tethering protein.The Journal of cell biology · 2015Article
- Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.The Journal of biological chemistry · 2014Article
- Loss of mitochondrial DNA in the yeast cardiolipin synthase crd1 mutant leads to up-regulation of the protein kinase Swe1p that regulates the G2/M transition.The Journal of biological chemistry · 2010Article
- Cytoplasmic bulk flow propels nuclei in mature hyphae of Neurospora crassa.Eukaryotic cell · 2009Article
- The RGS protein Crg2 regulates pheromone and cyclic AMP signaling in Cryptococcus neoformans.Eukaryotic cell · 2008Article
- Regulation of epidermal growth factor receptor degradation by heterotrimeric Galphas protein.Molecular biology of the cell · 2004Article
- Mmm2p, a mitochondrial outer membrane protein required for yeast mitochondrial shape and maintenance of mtDNA nucleoids.The Journal of cell biology · 2004Article
- Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism.Microbiology and molecular biology reviews : MMBR · 2004Review
- Mitochondrial dynamics.The New phytologist · 2003Review
- Maintenance of mitochondrial morphology is linked to maintenance of the mitochondrial genome in Saccharomyces cerevisiae.Genetics · 2002Article
- The Phox homology (PX) domain, a new player in phosphoinositide signalling.The Biochemical journal · 2001Review
- Article
- Desmin cytoskeleton in healthy and failing heart.Heart failure reviews · 2000Review
- Role of MMM1 in maintaining mitochondrial morphology in Neurospora crassa.Molecular biology of the cell · 2000Article
- Maintenance and integrity of the mitochondrial genome: a plethora of nuclear genes in the budding yeast.Microbiology and molecular biology reviews : MMBR · 2000Review
- A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae.The Journal of cell biology · 1999Article
- The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance.The Journal of cell biology · 1999Article
- The dynamin-related GTPase, Dnm1p, controls mitochondrial morphology in yeast.The Journal of cell biology · 1998Article
- The sorting of mitochondrial DNA and mitochondrial proteins in zygotes: preferential transmission of mitochondrial DNA to the medial bud.The Journal of cell biology · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mdml mutation causes temperature-sensitive growth and defective transfer of nuclei and mitochondria into developing buds of yeast cells at the nonpermissive temperature. The MDM1 gene was cloned by complementation, and its sequence revealed an open reading frame encoding a potential protein product of 51.5 kD. This protein displays amino acid sequence similarities to hamster vimentin and mouse epidermal keratin. Gene disruption demonstrated that MDM1 is essential for mitotic growth. Antibodies against the MDM1 protein recognized a 51-kD polypeptide that was localized by indirect immunofluorescence to a novel pattern of spots and punctate arrays distributed throughout the yeast cell cytoplasm. These structures disappeared after shifting mdm1 mutant cells to the nonpermissive temperature, although the cellular level of MDM1 protein was unchanged. Affinity-purified antibodies against MDM1 also specifically recognized intermediate filaments by indirect immunofluorescence of animal cells. These results suggest that novel cytoplasmic structures containing the MDM1 protein mediate organelle inheritance in yeast.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.