ArticleAnnals of surgery1992
Neurotensin augments intestinal regeneration after small bowel resection in rats.
Article in Annals of surgery, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 62 citations in OpenAlex.
- Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors.Oncotarget · 2015Article
- The effects of crude aqueous and alcohol extracts of Aloe vera on growth and abdominal viscera of suckling rats.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2012Article
- Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells.The Journal of biological chemistry · 2011Article
- Endocrine cells in atresic chick embryo intestine: histochemical and immunohistochemical study.European journal of histochemistry : EJH · 2009Review
- Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells.International journal of cancer · 2007Article
- Epidermal growth factor and bombesin act synergistically to support intestinal adaptation in rats with massive small bowel resection.Pediatric surgery international · 2005Article
- Intestinal adaptation after massive intestinal resection.Postgraduate medical journal · 2005Review
- Effect of aging on the adaptive and proliferative capacity of the small bowel.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2003Article
- Article
- A neurotensin antagonist, SR 48692, inhibits colonic responses to immobilization stress in rats.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Stimulation of pancreatic growth. Distal small bowel resection mediated by increased levels of cholecystokinin.Annals of surgery · 1996Article
- Characterization of promoter elements required for cell-specific expression of the neurotensin/neuromedin N gene in a human endocrine cell line.Molecular and cellular biology · 1995Article
- Bombesin improves survival from methotrexate-induced enterocolitis.Annals of surgery · 1994Article
- Trophic effects of neurotensin in massive bowel resection in the rat.Digestive diseases and sciences · 1994Article
- Developmental expression of the neurotensin gene in the rat liver.Annals of surgery · 1993Article
- Glucagon-like peptide 2 is a potent growth factor for small intestine and colon.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
- Epidermal growth factor and neurotensin induce microvillus hypertrophy following massive enterectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
- Enterotrophic effects of glucagon-like peptide 2 are enhanced by neurotensin.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Massive small bowel resection (SBR) is characterized by increased proliferation of residual gut mucosa and pancreas. Neurotensin (NT), a gut tridecapeptide, stimulates growth of normal gut mucosa and pancreas. This study examined whether NT affected growth of the small intestine and the pancreas after either distal or proximal SBR. Male Fischer 344 rats were divided into four groups. Group 1 underwent ileal transection with reanastomosis (SHAM) and group 2 underwent 70% distal SBR. Group 3 underwent SHAM operation (jejunal transection), and group 4 underwent 70% proximal SBR. After operation, each group was further subdivided to receive either saline (control) or NT (300 micrograms/kg) subcutaneously in gelatin every 8 hours for 7 days. At death, the pancreas and proximal jejunum (from groups 1 and 2) or distal ileum (from groups 3 and 4) were removed, weighed, and analyzed for DNA, RNA, and protein content. Both proximal and distal SBR significantly increased mucosal growth in the remnant intestine; a more pronounced effect was noted with proximal SBR. Administration of NT significantly augmented the adaptive changes in both groups of rats by mechanisms involving increases in both cell size (hypertrophy) and cell number (hyperplasia). Pancreatic growth was stimulated by distal (but not proximal) SBR; NT did not augment this response. The authors conclude that NT augments intestinal growth after SBR by mechanisms involving an increase in overall mucosal cellularity. Administration of NT may be therapeutically useful to enhance mucosal regeneration during the early period of adaptive hyperplasia after SBR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.