ArticleUrological research1992
Immunohistochemical detection of acidic fibroblast growth factor in bladder transitional cell carcinoma.
Article in Urological research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- A place for precision medicine in bladder cancer: targeting the FGFRs.Future oncology (London, England) · 2016Review
- A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells.Breast cancer research and treatment · 2014Article
- A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges.Advances in urology · 2012Article
- Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer.The American journal of pathology · 2010Article
- Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer.Cancer research · 2009Article
- Molecular pathways in bladder cancer.Urological research · 2004Review
- A rat model with an isolated bladder in situ.Surgery today · 1997Article
- Peptide growth factors in normal and hypertrophied bladder.World journal of urology · 1995Review
- Growth factors in bladder cancer.World journal of urology · 1995Review
- Hyperplasia of epithelium adjacent to transitional cell carcinoma can be induced by growth factors through paracrine pathways.Virchows Archiv : an international journal of pathology · 1994Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acidic fibroblast growth factor (aFGF) is a regulatory peptide which, on account of its structural homologies with the products of oncogenes, is involved in cell proliferation, differentiation, and motility. We previously reported the presence of aFGF in the urine of patients with transitional cell carcinoma (TCC). aFGF can also induce the motility of a rat-derived bladder carcinoma cell line (NBTII). This immunohistochemical study used polyclonal rabbit antibodies against acidic and basic FGF and peroxidase detection. Native NBTII nude mice xenografts and aFGF transfected NBTII (NFS14) nude mice xenografts were used as tissue controls for antibody specificity. The samples included 4 normal urothelia and 12 TCC. In addition, cytospins of 4 different tumoral cell lines of human bladder and normal bladder cells were stained. The results showed strong immunostaining in all tumoral urothelium samples using anti-aFGF and a very low amount of staining or none at all in healthy tissues. A primary analysis suggested that the strongest reaction was obtained in high-grade tumors (3 + vs + for lower-grade tumors). Using bFGF antibody, strong immunohistochemical staining was detected on basal membranes and stromal vessels and none in urothelium. These data confirm aFGF expression in the epithelial cell compartment of bladder cancer and the likely involvement of this regulatory peptide in the biology of TCC.
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