ArticleBritish journal of pharmacology1992
X-irradiation attenuates relaxant responses in the rabbit ear artery.
Article in British journal of pharmacology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Lower endothelium-dependent microvascular function in adult breast cancer patients receiving radiation therapy.Cardio-oncology (London, England) · 2021Article
- The Critical Role of Tetrahydrobiopterin (BH4) Metabolism in Modulating Radiosensitivity: BH4/NOS Axis as an Angel or a Devil.Frontiers in oncology · 2021Review
- Pathological effects of ionizing radiation: endothelial activation and dysfunction.Cellular and molecular life sciences : CMLS · 2019Review
- Radiation-induced afferent arteriolar endothelial-dependent dysfunction involves decreased epoxygenase metabolites.American journal of physiology. Heart and circulatory physiology · 2016Article
- Effect of electron radiation on vasomotor function of the left anterior descending coronary artery.Life sciences in space research · 2015Article
- Novel strategies to ameliorate radiation injury: a possible role for tetrahydrobiopterin.Current drug targets · 2010Review
- Mechanisms of endothelial dysfunction after ionized radiation: selective impairment of the nitric oxide component of endothelium-dependent vasodilation.British journal of pharmacology · 2003Article
- Effect of gamma knife irradiation on relaxation and contraction responses of the common carotid artery in the rat.Acta neurochirurgica · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The relaxant actions of acetylcholine, substance P and calcitonin gene-related peptide, and the levels of neuropeptide Y and calcitonin gene-related peptide were assessed in the rabbit central ear artery 1, 4 and 6 weeks after a single dose of 45 Gy X-irradiation, a dose similar to that used clinically in intraoperative radiotherapy. 2. Relaxant responses induced by acetylcholine and substance P (both endothelium-dependent) and calcitonin gene-related peptide (endothelium-independent) were reduced, and endogenous neuropeptide Y and calcitonin gene-related peptide levels were unaffected after X-irradiation. 3. The mechanism(s) by which a single dose of 45 Gy X-irradiation may selectively damage relaxant, but not direct, contractile responses of the smooth muscle (as we have shown previously) of the rabbit central ear artery are discussed.
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