ArticleVirchows Archiv. A, Pathological anatomy and histopathology1992
Light and electron microscopic immunolocalization of endothelial leucocyte adhesion molecule-1 in inflammatory bowel disease. Morphological evidence of active synthesis and secretion into vascular lumen.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Detection of ICAM-1 in experimentally induced colitis of ICAM-1-deficient and wild-type mice: an immunohistochemical study.The Histochemical journal · 2000Article
- Article
- Targeting an adenoviral gene vector to cytokine-activated vascular endothelium via E-selectin.Gene therapy · 1999Article
- Article
- Expression of E-selectin, sialyl Lewis X, and macrophage inflammatory protein-1alpha by colonic epithelial cells in ulcerative colitis.Digestive diseases and sciences · 1998Article
- Elevated serum concentrations of soluble selectin and immunoglobulin type adhesion molecules in patients with inflammatory bowel disease.Journal of gastroenterology · 1997Article
- Immunopathology of human inflammatory bowel disease.Springer seminars in immunopathology · 1997Review
- Increased mucosal concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), sE-selectin, and interleukin-8 in active ulcerative colitis.Digestive diseases and sciences · 1996Article
- Cell adhesion molecule expression by vascular endothelial cells as an immune/inflammatory reaction in human colon carcinoma.Japanese journal of cancer research : Gann · 1995Article
- Article
- Increased expression of cell adhesion molecule P-selectin in active inflammatory bowel disease.Gut · 1995Article
- Circulating soluble intercellular adhesion molecule-1 (sICAM-1) in active inflammatory bowel disease.Digestive diseases and sciences · 1994Article
- Serum Concentration and Chemotactic Activity of E-selectin (CD62E) in Inflammatory Bowel Disease.Mediators of inflammation · 1994Article
- A study of the Interaction Between Cetirizine and Plasma Membrane of Eosinophils, Neutrophils, Platelets and Lymphocytes using A fluorescence Technique.Mediators of inflammation · 1994Article
- Altered expression of cell adhesion molecules in uninvolved gut in inflammatory bowel disease.Clinical and experimental immunology · 1993Article
- Time-course of adhesion molecule expression in rectal mucosa of gluten-sensitive subjects after gluten challenge.Clinical and experimental immunology · 1993Article
- Glomeruloid structures as vascular reaction in human gastrointestinal carcinoma.Japanese journal of cancer research : Gann · 1992Article
- Soluble adhesion molecules in inflammatory bowel disease.Irish journal of medical scienceArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endothelial leucocyte adhesion molecule-1 (ELAM-1) is a rapidly inducible adhesion molecule for neutrophils in vascular endothelial cells. We investigated its immunohistochemical localization in 17 cases of inflammatory bowel disease. ELAM-1 was preferentially expressed in venules in actively inflamed mucosa and granulation tissue. Most capillaries were negative for ELAM-1. In areas with mild inflammation its expression diminished markedly and in normal mucosa of the colon and small intestine its expression was sparse. Electron microscopically, venules in active inflammation had swollen endothelial cells with well-developed rough endoplasmic reticulum. Immunoelectron microscopy revealed ELAM-1 localization along the luminal plasma membrane and in rough endoplasmic reticulum and round granules, findings suggestive of active production in endothelial cells. Furthermore, exocytosis of immunoreactive substance into the lumen was confirmed. Our study suggests that venules in actively inflamed area play an important role in eliciting and/or maintaining acute inflammatory processes by active permeation of neutrophils from the blood stream into the tissue, and that ELAM-1 may be a secretory protein as well as a transmembrane receptor protein.
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