ArticleThe Journal of experimental medicine1992
Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.
Article in The Journal of experimental medicine, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 149 citations in OpenAlex.
- FINER: enhancing the prediction of tissue-specific functions of isoforms by refining isoform interaction networks.NAR genomics and bioinformatics · 2021Article
- Fyn Kinase: A Potential Therapeutic Target in Acute Kidney Injury.Biomolecules & therapeutics · 2020Review
- Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation.Communications biology · 2020Article
- Morpholino-based correction of hypomorphic ZAP70 mutation in an adult with combined immunodeficiency.The Journal of allergy and clinical immunology · 2017Article
- Selective induction of alternatively spliced FynT isoform by TNF facilitates persistent inflammatory responses in astrocytes.Scientific reports · 2017Article
- Regulatory region genetic variation is associated with FYN expression in Alzheimer's disease.Neurobiology of aging · 2017Article
- Transcriptome-wide RNA interaction profiling reveals physical and functional targets of hnRNP L in human T cells.Molecular and cellular biology · 2014Article
- Control of alternative splicing in immune responses: many regulators, many predictions, much still to learn.Immunological reviews · 2013Review
- Intersecting roles of protein tyrosine kinase and calcium signaling during fertilization.Cell calcium · 2013Review
- Tebrophen--an old polyphenol drug with anticancer potential.Molecules (Basel, Switzerland) · 2012Article
- Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Alternative splicing modulates autoinhibition and SH3 accessibility in the Src kinase Fyn.Molecular and cellular biology · 2009Article
- Oncogenic ras blocks the cAMP pathway and dedifferentiates thyroid cells via an impairment of pax8 transcriptional activity.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Review
- Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts.The Journal of biological chemistry · 2008Article
- Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes.Molecular and cellular biology · 2007Article
- Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor.Molecular and cellular biology · 2006Article
- Article
- Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent observations suggest that the src-related tyrosine protein kinase p59fyn may be involved in antigen-induced T lymphocyte activation. As a result of alternative splicing, p59fyn exists as two isoforms that differ exclusively within a short sequence spanning the end of the Src Homology 2 (SH2) region and the beginning of the tyrosine protein kinase domain. While one p59fyn isoform (fynB) is highly expressed in brain, the alternative product (fynT) is principally found in T lymphocytes. To further understand the role of p59fyn in T cell activation and to test the hypothesis that p59fynT serves a tissue-specific function in T lymphocytes, we have examined the effects of expression of activated versions (tyrosine 528 to phenylalanine 528 mutants) of either form of p59fyn on the physiology of an antigen-specific mouse T cell hybridoma. Our results demonstrated that the two forms of fyn, expressed in equivalent amounts, efficiently enhanced antibody-induced T cell receptor (TCR)-mediated signals. In contrast, only p59fynT increased interleukin 2 production in response to antigen stimulation. This finding implies that the distinct p59fyn isoform expressed in T lymphocytes regulates the coupling of TCR stimulation by antigen/major histocompatibility complex to lymphokine production.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.