ArticleJournal of comparative physiology. A, Sensory, neural, and behavioral physiology1992
Patch-clamp recordings of spiking and nonspiking interneurons from rabbit olfactory bulb slices: GABA- and other transmitter receptors.
Article in Journal of comparative physiology. A, Sensory, neural, and behavioral physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 30 citations in OpenAlex.
- Development of the mammalian main olfactory bulb.Development (Cambridge, England) · 2022Review
- Article
- Light/Clock Influences Membrane Potential Dynamics to Regulate Sleep States.Frontiers in neurology · 2021Review
- Differential effect of brief electrical stimulation on voltage-gated potassium channels.Journal of neurophysiology · 2017Article
- Neurogliogenesis in the mature olfactory system: a possible protective role against infection and toxic dust.Brain research reviews · 2009Review
- Dopamine receptor subtypes modulate olfactory bulb gamma-aminobutyric acid type A receptors.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Patch-clamp study on membrane properties and transmitter activated currents of rabbit area postrema neurons.Journal of comparative physiology. A, Sensory, neural, and behavioral physiology · 1996Article
- Patch clamp study of histamine activated potassium currents on rabbit olfactory bulb neurons.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Different spatial patterns of [Ca2+] increase caused by N- and L-type Ca2+ channel activation in frog olfactory bulb neurones.The Journal of physiology · 1995Article
- Patch-clamp recordings of spiking and nonspiking interneurons from rabbit olfactory bulb slices: membrane properties and ionic currents.Journal of comparative physiology. A, Sensory, neural, and behavioral physiology · 1992Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transmitter receptor ion channels from previously identified rabbit olfactory bulb neurons were studied by using a thin slice preparation in combination with patch-clamp measurements. PG cells, which closely resembled previously described periglomerular interneurons in their morphology, responded to microapplication of GABA, acetylcholine, norepinephrine and glycine with the activation of distinct ionic currents. JG cells, which belong either to the class of short axon cells or external tufted cells, never showed GABA responses. In mitral cells ionic currents activated by GABA, acetylcholine, norepinephrine and glutamate could be elicited. Further measurements of GABA-activated currents of PG cells were made and indicated that these cells expressed two different types of GABA receptors: one which showed fast desensitization with a decay time constant of about 5 s, and one which slowly desensitized with a decay time constant of about 20-30 s. Both types were completely inhibited by bicuculline methiodide (50 microM). GABA receptors were not blocked by Zn2+ (0.1 mM). From the dose-response relationship of the peak GABA-activated currents, an apparent dissociation constant of 50 microM was derived. From single channel measurements in excised outside-out patches, a single channel conductance of GABA-activated Cl- currents of 24 pS was obtained during continuous application of the agonist. Single channel events had a mean open time of 1.9 ms.
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