ArticleThe American journal of pathology1992
Immunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibody.
Article in The American journal of pathology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 60 citations in OpenAlex.
- Inhibition of Pore-Forming Proteins.Toxins · 2019Review
- Immune-mediated vascular injury and dysfunction in transplant arteriosclerosis.Frontiers in immunology · 2014Review
- Phosphoantigen/IL2 expansion and differentiation of Vγ2Vδ2 T cells increase resistance to tuberculosis in nonhuman primates.PLoS pathogens · 2013Article
- Antiviral responses following L-leucyl-L-leucine methyl esther (LLME)-treated lymphocyte infusions: graft-versus-infection without graft-versus-host disease.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2009Article
- Perforin expression in peripheral blood lymphatic cells of patients subjected to laparoscopic or open cholecystectomy.Mediators of inflammation · 2009Article
- Identification of an astrocyte cell population from human brain that expresses perforin, a cytotoxic protein implicated in immune defense.The Journal of experimental medicine · 1998Article
- Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.The EMBO journal · 1997Article
- Differential expression of perforin in muscle-infiltrating T cells in polymyositis and dermatomyositis.The Journal of clinical investigation · 1996Article
- Perforin expression by thyroid-infiltrating T cells in autoimmune thyroid disease.Clinical and experimental immunology · 1994Article
- Development of four donor-specific phenotypes in human long-term lymphokine-activated killer cell cultures.Cancer immunology, immunotherapy : CII · 1994Article
- Characterization of a novel monoclonal antibody against human perforin using transfected cell lines.Immunology · 1994Article
- Angiocentric lymphoma with granulomatous panniculitis in the skin expressing natural killer cell and large granular T-cell phenotypes.Virchows Archiv : an international journal of pathology · 1994Article
- Cytotoxic potential of intraepithelial lymphocytes (IELs). Presence of TIA-1, the cytolytic granule-associated protein, in human IELs in normal and diseased intestine.The American journal of pathology · 1993Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perforin is a potent cytolytic pore-forming protein expressed in cytoplasmic granules of cytotoxic T lymphocytes and natural killer cells. A new monoclonal antibody raised against human perforin was used to detect both in vitro and in vivo perforin expression in cytotoxic cells. Immunohistochemical analysis of human peripheral blood mononuclear cells cultured in recombinant interleukin-2 (rIL-2) showed strong granular cytoplasmic staining of the IL-2 activated cytotoxic cells. Fresh-frozen tissue sections from patients with heart allograft rejection were also stained. Strong granular cytoplasmic staining of the mononuclear inflammatory infiltrate characteristic for perforin in cardiac allograft rejection was observed. The detection and quantitative analysis of perforin-associated cytotoxic cells by the human anti-perforin monoclonal antibody will help to evaluate the significance of these functionally distinct cytotoxic cells in human tissue.
Indexed as
Identifiers
1374586PMC1886520W1574860301What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.