ArticleThe American journal of pathology1992
Infiltration of helper/inducer T lymphocytes heralds central nervous system damage in human T-cell leukemia virus infection.
Article in The American journal of pathology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy.PLoS pathogens · 2012Trial
- Zidovudine plus lamivudine in Human T-Lymphotropic Virus type-I-associated myelopathy: a randomised trial.Retrovirology · 2006Trial
- Immunological and Neurological Signatures of the Co-Infection of HIV and HTLV: Current Insights and Future Perspectives.Viruses · 2025Review
- HTLV-1 induces an inflammatory CD4+CD8+ T cell population in HTLV-1-associated myelopathy.JCI insight · 2024Article
- Identification of dysregulated pathways underlying HTLV-1-associated myelopathy/tropical spastic paraparesis through co-expression network analysis.Journal of neurovirology · 2021Article
- Article
- Human T-cell leukaemia virus type 1: parasitism and pathogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Effect of Pulsed Methylprednisolone on Pain, in Patients with HTLV-1-Associated Myelopathy.PloS one · 2016Article
- HAM/TSP-derived HTLV-1-infected T cell lines promote morphological and functional changes in human astrocytes cell lines: possible role in the enhanced T cells recruitment into Central Nervous System.Virology journal · 2015Article
- Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis.Journal of virology · 2008Article
- Treatment of HTLV-I-associated myelopathy/tropical spastic paraparesis: toward rational targeted therapy.Neurologic clinics · 2008Review
- Human T-lymphotropic virus 1 neurologic disease.Current treatment options in neurology · 2008Article
- Abnormalities of spinal magnetic resonance images implicate clinical variability in human T-cell lymphotropic virus type I-associated myelopathy.Journal of neurovirology · 2007Article
- Cellular immune response to HTLV-1.Oncogene · 2005Review
- Human T-lymphotropic virus type 1 (HTLV-1): persistence and immune control.International journal of hematology · 2003Review
- High circulating frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4+ T cells in patients with HTLV-1-associated neurological disease.Journal of virology · 2003Article
- Mechanisms of T-cell activation by human T-cell lymphotropic virus type I.Microbiology and molecular biology reviews : MMBR · 1999Review
- HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Pathogenesis and treatment of HTLV-I associated myelopathy.Sexually transmitted infections · 1998Review
- Differential transactivation of the intercellular adhesion molecule 1 gene promoter by Tax1 and Tax2 of human T-cell leukemia viruses.Journal of virology · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular infiltrates in new and old lesions in two cases of human T-cell leukemia virus associated myelopathy (HAM) were analyzed with anti-CD3 antibody and OPD4 antibody recognizing CD4 + CD45RO + T lymphocytes. A subset of CD4 lymphocytes with helper/inducer function and labeled with OPD4 constitutes up to 65% of CD3 cells in new lesions in the pons and the cervical cord. In contrast, nonhelper cells and macrophages were dominant in long-standing spinal cord lesions of these HAM cases and inflammatory lesions in two cases of Japanese encephalitis. Thus, unlike in viral infections, the central nervous system (CNS) tissue damage associated with human T-cell leukemia virus (HTLV-1) infection appeared to be heralded by the infiltration of helper/inducer T cells.
Indexed as
Identifiers
1374584PMC1886515W2337996378What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.