ArticleThe Journal of cell biology1992
Specific association of the proto-oncogene product pp60c-src with an intracellular organelle, the PC12 synaptic vesicle.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 76 citations in OpenAlex.
- Increased activity of the vesicular soluble N-ethylmaleimide-sensitive factor attachment protein receptor TI-VAMP/VAMP7 by tyrosine phosphorylation in the Longin domain.The Journal of biological chemistry · 2013Article
- Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actin.The Journal of cell biology · 2013Article
- Regulation of SRC family kinases in human cancers.Journal of signal transduction · 2011Article
- CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain.The Journal of cell biology · 2004Article
- Regulation of cytochrome c oxidase activity by c-Src in osteoclasts.The Journal of cell biology · 2003Article
- Synaptophysin regulates activity-dependent synapse formation in cultured hippocampal neurons.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A src family tyrosine kinase inhibits neurotransmitter release from neuronal cells.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Src, Fyn, and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Review
- Nonreceptor tyrosine protein kinase pp60c-src in spatial learning: synapse-specific changes in its gene expression, tyrosine phosphorylation, and protein-protein interactions.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity.The EMBO journal · 2000Article
- Trafficking of an acylated cytosolic protein: newly synthesized p56(lck) travels to the plasma membrane via the exocytic pathway.The Journal of cell biology · 1999Article
- Identification of a new Pyk2 target protein with Arf-GAP activity.Molecular and cellular biology · 1999Article
- ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.Molecular and cellular biology · 1998Article
- Sorting and storage during secretory granule biogenesis: looking backward and looking forward.The Biochemical journal · 1998Review
- Src interacts with dynamin and synapsin in neuronal cells.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Substrate recognition by osteoclast precursors induces C-src/microtubule association.The Journal of cell biology · 1997Article
- Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The protein product of the proto-oncogene c-src is a membrane-associated tyrosine kinase of unknown function. Identification of pp60c-src target membranes may elucidate the function of the c-src protein. The available evidence indicates that pp60c-src associates with distinct membranes within single cell types and has different distributions in different cell types. Our experiments demonstrate targeting of pp60c-src to an isolatable and biochemically identified membrane fraction in the neuroendocrine cell line PC12. The c-src protein was found to be specifically associated with synaptic vesicles since: (a) the pp60c-src immunofluorescent pattern overlapped with a synaptic vesicle marker, synaptophysin; (b) a significant proportion (44%) of the pp60c-src from PC12 but not fibroblast postnuclear supernatants was recovered in a small vesicle fraction; (c) an anti-synaptophysin cytoplasmic domain antibody immunodepleted all of the pp60c-src vesicles in this fraction, and (d) pp60c-src copurified during a 100-fold purification of PC12 synaptic vesicles. These results suggest a role for the c-src protein in the regulation of synaptic vesicle function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.