ArticleMolecular and cellular biology1992
Selective translational control and nonspecific posttranscriptional regulation of ribosomal protein gene expression during development and regeneration of rat liver.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 82 citations in OpenAlex.
- TGFβ pathway represses hepatic ribosome biogenesis and protein synthesis by regulating p70S6K-S6RP proteins.Cellular & molecular biology letters · 2026Article
- LARP1 senses free ribosomes to coordinate supply and demand of ribosomal proteins.bioRxiv : the preprint server for biology · 2023Article
- The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation.Stem cell reports · 2023Article
- CDK1 couples proliferation with protein synthesis.The Journal of cell biology · 2020Article
- LARP1 on TOP of ribosome production.Wiley interdisciplinary reviews. RNA · 2018Review
- Cylindrospermopsin toxicity in mice following a 90-d oral exposure.Journal of toxicology and environmental health. Part A · 2018Article
- Skeletal muscle atrophy: disease-induced mechanisms may mask disuse atrophy.Journal of muscle research and cell motility · 2015Review
- S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy.The Journal of clinical investigation · 2011Article
- Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction.Nature cell biology · 2009Article
- Decreased RNA, and increased RNA oxidation, in ribosomes from early Alzheimer's disease.Neurochemical research · 2006Article
- Ribosome dysfunction is an early event in Alzheimer's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis.Genes & development · 2005Article
- Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation.Molecular and cellular biology · 2002Article
- Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation.Molecular and cellular biology · 2001Article
- Iron regulatory proteins in pathobiology.The Biochemical journal · 2000Review
- Nuclear and nucleolar targeting of human ribosomal protein S25: common features shared with HIV-1 regulatory proteins.Oncogene · 1999Article
- Overexpression of initiation factor eIF-4E does not relieve the translational repression of ribosomal protein mRNAs in quiescent cells.Gene expression · 1995Article
- Vertebrate mRNAs with a 5'-terminal pyrimidine tract are candidates for translational repression in quiescent cells: characterization of the translational cis-regulatory element.Molecular and cellular biology · 1994Article
- Differential regulation of multiple gap junction transcripts and proteins during rat liver regeneration.The Journal of cell biology · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian liver development is accompanied by a transition from rapid growth in the fetus to a quiescent state in the adult. However, extensive proliferation can be induced in the adult liver by partial hepatectomy. In this study, we examined the regulation of ribosomal protein (rp) gene expression in the developing and regenerating rat liver. Our results indicate that the translation of rp mRNAs is selectively repressed by about 70% upon development from fetal to adult life, as illustrated by the decrease in ribosomal loading. In addition, the relative abundance of these mRNAs, like that of several other, but not all, housekeeping mRNAs, declines during development through a posttranscriptional mechanism. When liver cells commence growth following partial hepatectomy, translation of rp mRNAs is resumed to near-maximal capacity, as judged by their very efficient recruitment into polysomes. The concomitant increase in the abundance rp mRNAs under these circumstances is achieved by a posttranscriptional mechanism. The apparent fluctuations in the translation efficiency of rp mRNAs are accompanied by parallel changes in the expression of the genes encoding the initiation factors eIF-4E and eIF-4A. Our results indicate that selective translational control of rp mRNAs in mammals is not confined to manipulated cells in culture but constitutes an important regulatory mechanism operating in vivo in the course of liver development and regeneration.
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