ArticleProceedings of the National Academy of Sciences of the United States of America1992
Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 142 citations in OpenAlex.
- Review
- VEGF, FGF-2 and TGFβ expression in the normal and regenerating epidermis of geckos: implications for epidermal homeostasis and wound healing in reptiles.Journal of anatomy · 2018Article
- Advanced Growth Factor Delivery Systems in Wound Management and Skin Regeneration.Molecules (Basel, Switzerland) · 2017Review
- Augmenting tendon and ligament repair with platelet-rich plasma (PRP).Muscles, ligaments and tendons journal · 2013Review
- Fibroblast growth factor 2 causes G2/M cell cycle arrest in ras-driven tumor cells through a Src-dependent pathway.PloS one · 2013Article
- A novel mechanism of sequestering fibroblast growth factor 2 by glypican in lipid rafts, allowing skeletal muscle differentiation.Molecular and cellular biology · 2010Article
- Article
- Article
- Evaluation of the fibroblast growth factor system as a potential target for therapy in human prostate cancer.British journal of cancer · 2005Article
- Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities.Human molecular genetics · 2004Article
- Article
- Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis.Molecular and cellular biology · 2001Article
- Article
- Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts.The Journal of cell biology · 2000Article
- Oligomerization reduces heparin affinity but enhances receptor binding of fibroblast growth factor 2.The Biochemical journal · 2000Article
- Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Transformation of rabbit vascular smooth muscle cells by human cytomegalovirus morphological transforming region I.The American journal of pathology · 1997Article
- Lack of acidic fibroblast growth factor activation by heparan sulfate species from diabetic rat skin.Glycoconjugate journal · 1997Article
- Suppression of autocrine and paracrine functions of basic fibroblast growth factor by stable expression of perlecan antisense cDNA.Molecular and cellular biology · 1997Article
- Fibroblast growth factor 2 in breast cancer: occurrence and prognostic significance.British journal of cancer · 1997Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The bek gene encodes a member of the high-affinity fibroblast growth factor receptor family. The BEK/FGFR-2 receptor is a membrane-spanning tyrosine kinase with the typical features of FGF receptors. We have cloned a murine bek cDNA and expressed it in receptor-negative Chinese hamster ovary cells and in 32D myeloid cells. The BEK receptor expressed in Chinese hamster ovary cells binds acidic FGF, basic FGF, and Kaposi FGF equally well but does not bind keratinocyte growth factor or FGF-5 appreciably. Upon treatment with basic FGF or Kaposi FGF, the BEK receptor is phosphorylated and a mitogenic response is achieved. Heparan sulfate proteoglycans have been shown to play an obligate role in basic FGF binding to the high-affinity FLG receptor. Unlike the BEK-expressing Chinese hamster ovary cells, 32D cells expressing the BEK receptor require the addition of exogenous heparin in order to grow in the presence of basic FGF or Kaposi FGF. We show that the addition of heparin greatly enhances the binding of radio-labeled basic FGF to the receptor. Thus the BEK receptor, like FLG, also requires an interaction with heparan sulfate proteoglycans to facilitate binding to its ligands.
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