ArticleProceedings of the National Academy of Sciences of the United States of America1992
Neuromodulatory loop mediated by nerve growth factor and interleukin 6 in thymic stromal cell cultures.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 56 citations in OpenAlex.
- Thymus Regeneration and Future Challenges.Stem cell reviews and reports · 2020Review
- Thymic Epithelial Tumors phenotype relies on miR-145-5p epigenetic regulation.Molecular cancer · 2017Article
- Review
- Thymocyte depletion affects neurotrophin receptor expression in thymic stromal cells.Journal of anatomy · 2006Article
- Neurotrophins and the immune system.Journal of anatomy · 2003Review
- Upregulation of TrkA neurotrophin receptor expression in the thymic subcapsular, paraseptal, perivascular, and cortical epithelial cells during thymus regeneration.Histochemistry and cell biology · 2003Article
- REN: a novel, developmentally regulated gene that promotes neural cell differentiation.The Journal of cell biology · 2002Article
- Is IL-6 both a cytokine and a neurotrophic factor?The Journal of experimental medicine · 1996Review
- Epidermal growth factor promotes a neural phenotype in thymic epithelial cells and enhances neuropoietic cytokine expression.The Journal of cell biology · 1995Article
- Positive and negative regulation of the composite octamer motif of the interleukin 2 enhancer by AP-1, Oct-2, and retinoic acid receptor.The Journal of experimental medicine · 1994Article
- The thymic education of developing T cells in self neuroendocrine principles.Journal of endocrinological investigation · 1992Review
- Nerve growth factor: a neurokine orchestrating neuroimmune-endocrine functions.Molecular neurobiologyReview
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural crest cell derivatives have been suggested to be involved in thymus development. We established nonlymphoid thymic stromal cell cultures capable of supporting T-cell differentiation. In these nonlymphoid cell cultures, we identified cells with phenotypic and biochemical markers specific for neuronal cells. Neurofilament mRNA and 68- and 160-kDa neurofilament proteins, as well as 74-kDa synapsin I isoform, were expressed in many of the cultured cells. For example, neurofilament immunoreactivity was detected in 20-30% of the cells. To see whether thymic neuronal-like cells were involved in a neural differentiation pathway, we investigated the effect of nerve growth factor (NGF) and interleukin 6 (IL-6), two known neurotrophic factors. The expression of the above-described neural markers was enhanced by NGF and IL-6, which we report to be produced in an autocrine way by thymic stromal cell cultures. Finally, we found that IL-6 gene expression in these cell cultures was enhanced by NGF. Evidence is thus offered of a neuromodulatory loop within the thymic stromal cell population supported by local production of NGF and IL-6 and involving neural cell elements. Interestingly, IL-6, which is known to be implicated in thymocyte differentiation, also displays a neuromodulatory activity on thymic stromal cells, suggesting a multivalent role for this cytokine within the thymus.
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