ArticleEuropean biophysics journal : EBJ1992
Ionic permeability of the mitochondrial outer membrane.
Article in European biophysics journal : EBJ, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- In vivo brain imaging of mitochondrial CaBiochimica et biophysica acta. Molecular cell research · 2021Review
- Electrophysiological properties of the mitochondrial permeability transition pores: Channel diversity and disease implication.Biochimica et biophysica acta. Bioenergetics · 2021Review
- Diversity of mitochondrial Ca²⁺ signaling in rat neonatal cardiomyocytes: evidence from a genetically directed Ca²⁺ probe, mitycam-E31Q.Cell calcium · 2014Article
- Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria.The Journal of biological chemistry · 2010Article
- Reflections on VDAC as a voltage-gated channel and a mitochondrial regulator.Journal of bioenergetics and biomembranes · 2008Review
- Mitochondrial ion channels.Annual review of physiology · 2007Review
- Mitochondrial ion channels: gatekeepers of life and death.Physiology (Bethesda, Md.) · 2005Review
- Pathophysiological and protective roles of mitochondrial ion channels.The Journal of physiology · 2000Review
- Extramitochondrial porin: facts and hypotheses.Journal of bioenergetics and biomembranes · 2000Review
- Evidence for three different electrophoretic pathways in yeast mitochondria: ion specificity and inhibitor sensitivity.Journal of bioenergetics and biomembranes · 1993Article
- Reconstitution of the native mitochondrial outer membrane in planar bilayers. Comparison with the outer membrane in a patch pipette and effect of aluminum compounds.The Journal of membrane biology · 1993Article
- High-conductance pathways in mitochondrial membranes.Journal of bioenergetics and biomembranes · 1992Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ionic permeability of the outer mitochondrial membrane (OMM) was studied with the patch clamp technique. Electrical recording of intact mitochondria (hence of the outer membrane (OM], derived from mouse liver, showed the presence of currents corresponding to low conductances (less than 50 pS), as well as of four distinct conductances of 99 pS, 152 pS, 220 pS and 307 pS (in 150 mM KCl). The latter were voltage gated, being open preferentially at positive (pipette) potentials. Very similar currents were found by patch clamping liposomes containing the isolated OM derived from rat brain mitochondria. Here a conductance of approximately 530 pS, resembling in its electrical characteristics a conductance already attributed to mitochondrial contact sites (Moran et al. 1990), was also detected. Immunoblot assays of mitochondria and of the isolated OM with antibodies against the outer membrane voltage-dependent anion channel (VDAC) (Colombini 1979), showed the presence of the anion channel in each case. However, the typical electrical behaviour displayed by such a channel in planar bilayers could not be detected under our experimental conditions. From this study, the permeability of the OMM appears different from what has been reported hitherto, yet is more in line with that multifarious and dynamic structure which apparently should belong to it, at least within the framework of mitochondrial biogenesis (Pfanner and Neupert 1990).
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