ArticleBritish journal of pharmacology1992
Inhibition of neurogenic plasma exudation in guinea-pig airways by CP-96,345, a new non-peptide NK1 receptor antagonist.
Article in British journal of pharmacology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 105 citations in OpenAlex.
- Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways.British journal of pharmacology · 2008Article
- Positive interaction of the beta2-agonist CHF 4226.01 with budesonide in the control of bronchoconstriction induced by acetaldehyde in the guinea-pigs.British journal of pharmacology · 2005Article
- A new pharyngitis model using capsaicin in rats.General pharmacology · 1998Article
- Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation.The Journal of clinical investigation · 1996Article
- Substance P contributes to rapidly adapting receptor responses to pulmonary venous congestion in rabbits.The Journal of physiology · 1996Article
- Involvement of hydroxyl radicals in neurogenic airway plasma exudation and bronchoconstriction in guinea-pigs in vivo.British journal of pharmacology · 1996Article
- The non-peptide NK1 receptor antagonist SR140333 produces long-lasting inhibition of neurogenic inflammation, but does not influence acute chemo- or thermonociception in rats.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Differences in the distribution and characteristics of tachykinin NK1 binding sites between human and guinea pig lung.British journal of pharmacology · 1994Article
- Differential effects of phosphoramidon and captopril on NK1 receptor-mediated plasma extravasation in the rat trachea.Agents and actions · 1994Article
- NK1 receptors mediate tachykinin-induced plasma extravasation in the rat knee joint.Agents and actions · 1993Article
- Role played by NK2 receptor and cyclooxygenase activation in bradykinin B2 receptor mediated-airway effects in guinea pigs.Agents and actions · 1993Article
- Tachykinin receptor antagonists inhibit hyperpnea-induced bronchoconstriction in guinea pigs.The Journal of clinical investigation · 1993Article
- Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo.British journal of pharmacology · 1993Article
- NK2 receptors mediate plasma extravasation in guinea-pig lower airways.British journal of pharmacology · 1993Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new non-peptide tachykinin antagonist, CP-96,345, inhibited airway plasma exudation induced in guinea-pigs by i.v. substance P in a dose-dependent manner with dose-ratios in the main bronchi of 5 at 1 nmol kg-1 and 19 at 100 nmol kg-1. At 100 nmol kg-1, CP-96,345 completely inhibited plasma exudation induced by either electrical stimulation of the cervical vagus nerves or i.v. capsaicin, indicating inhibition of the effects of endogenous tachykinins, but did not inhibit the bronchoconstrictor response to neurokinin A, suggesting selectivity for NK1 receptors. CP-96,345 may be useful in examining the role of endogenous tachykinins in vivo.
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