ArticleThe EMBO journal1992
Modulation of homeobox gene expression alters the phenotype of human hematopoietic cell lines.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 78 citations in OpenAlex.
- Hox genes in hematopoiesis and leukemogenesis.Oncogene · 2007Review
- Folate modulates Hox gene-controlled skeletal phenotypes.Genesis (New York, N.Y. : 2000) · 2004Article
- Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia.Molecular and cellular biology · 2002Article
- Expression pattern of HOXB6 homeobox gene in myelomonocytic differentiation and acute myeloid leukemia.Leukemia · 2002Article
- BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene.Molecular and cellular biology · 2002Article
- Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2.The Journal of experimental medicine · 2000Article
- A differential screen for ligand-regulated genes: identification of HoxA10 as a target of vitamin D3 induction in myeloid leukemic cells.Molecular and cellular biology · 1998Article
- HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas.The American journal of pathology · 1997Article
- Inhibition of DLX-7 homeobox gene causes decreased expression of GATA-1 and c-myc genes and apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Article
- A homeobox gene of the Antennapedia class is required for human adult erythropoiesis.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Homeobox genes are expressed in the retina and brain of adult goldfish.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells.Nucleic acids research · 1992Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We have previously reported that certain genes of the HOX2 cluster of homeobox genes on human chromosome 17 are specifically expressed in human leukemic cell lines with erythroid potential, suggesting that these genes are involved in hematopoietic differentiation. We now show that the expression of the HOX 2.2 gene decreases during erythropoietin-induced differentiation of the erythroid cell line MB02. In order to study the role of the HOX 2.2 homeobox gene in hematopoiesis, vectors producing sense or antisense transcripts were introduced into K562 and HEL cells, pluripotent lines with erythroid and myeloid features. Overexpression of HOX 2.2 is associated with loss of erythroid features in both lines and an increase in certain myelomonocytic markers in K562 cells. Expression of antisense HOX 2.2 is associated with an increase in erythroid features in HEL cells and a mild decrease in myeloid characteristics in K562 cells. Overexpression of the adjacent HOX 2.1 gene in K562 cells does not produce similar phenotype changes. These data demonstrate that modulation of a specific HOX 2 homeobox gene can change the phenotype of somatic cells and suggest that certain HOX 2 genes play a role in blood cell differentiation.
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