ArticleThe EMBO journal1992
Distinct modes of transcription read through or terminate at the c-myc attenuator.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 48 citations in OpenAlex.
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- Counter-regulatory effect of sodium butyrate on tumour necrosis factor-alpha (TNF-alpha)-induced complement C3 and factor B biosynthesis in human intestinal epithelial cells.Clinical and experimental immunology · 1999Article
- Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro.The EMBO journal · 1998Article
- Poly(A)-driven and poly(A)-assisted termination: two different modes of poly(A)-dependent transcription termination.Molecular and cellular biology · 1998Article
- Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures.The Biochemical journal · 1996Article
- Distinct activated and non-activated RNA polymerase II complexes in yeast.The EMBO journal · 1996Article
- TFIIH functions in regulating transcriptional elongation by RNA polymerase II in Xenopus oocytes.Molecular and cellular biology · 1996Article
- Phosphorylation dependence of the initiation of productive transcription of Balbiani ring 2 genes in living cells.Chromosoma · 1996Article
- Variable pause positions of RNA polymerase II lie proximal to the c-myc promoter irrespective of transcriptional activity.Nucleic acids research · 1995Article
- Presence of negative torsional tension in the promoter region of the transcriptionally poised dihydrofolate reductase gene in vivo.Nucleic acids research · 1995Article
- The effect of cyclic-AMP on the regulation of c-myc expression in T lymphoma cells.The Journal of clinical investigation · 1995Article
- Control of transcription arrest in intron 1 of the murine adenosine deaminase gene.Molecular and cellular biology · 1994Article
- Distinct properties of c-myc transcriptional elongation are revealed in Xenopus oocytes and mammalian cells and by template titration, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), and promoter mutagenesis.Molecular and cellular biology · 1993Article
- Regulation of eukaryotic gene expression by transcriptional attenuation.Molecular biology of the cell · 1993Review
- A novel transcription factor, OB2-1, is required for overexpression of the proto-oncogene c-erbB-2 in mammary tumour lines.The EMBO journal · 1993Article
- Functional analysis of a stable transcription arrest site in the first intron of the murine adenosine deaminase gene.Molecular and cellular biology · 1993Article
- Transcription elongation in the human c-myc gene is governed by overall transcription initiation levels in Xenopus oocytes.Molecular and cellular biology · 1993Article
- Sequences in the human c-myc P2 promoter affect the elongation and premature termination of transcripts initiated from the upstream P1 promoter.Molecular and cellular biology · 1992Article
- Hold back of RNA polymerase II at the transcription start site mediates down-regulation of c-myc in vivo.The EMBO journal · 1992Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Premature termination of transcription by RNA polymerase II (pol II) occurs in the 5' region of many viral and cellular genes. Modulation of this process, or attenuation, is an important means of transcriptional control, but its mechanism is unknown. Using injected Xenopus oocytes, the efficiency of the mouse c-myc attenuator was tested when it was placed at various distances from the transcription initiation site. The attenuator functioned with each of six different pol II promoters tested; however, termination efficiency declined markedly when it was placed more than approximately 400 bases from the start site. This decline in attenuator function with distance from the start site coincided with increased sensitivity to the pol II inhibitor 5,6-dichloro-1-beta-D-ribofuranosyl benzimidazole (DRB). Thus transcription complexes situated further from the promoter appear to have a lower ability to recognize the attenuator and a greater sensitivity to DRB. Furthermore, polymerases which have read through one attenuation site have a reduced ability to terminate at a second site. The results imply that a discrete subset of elongation complexes is capable of premature termination, and that this subset exists only within the first few hundred bases of the transcription unit. Regulation of termination efficiency may be effected by changing the balance between the two modes of transcription committed either to read through or to terminate prematurely.
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