ArticleThe Biochemical journal1992
Natural polyamines stimulate G-proteins.
Article in The Biochemical journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Exercise training preserves ischemic preconditioning in aged rat hearts by restoring the myocardial polyamine pool.Oxidative medicine and cellular longevity · 2014Article
- L-ornithine derived polyamines in cystic fibrosis airways.PloS one · 2012Article
- Cytoskeleton in mast cell signaling.Frontiers in immunology · 2012Article
- Advanced glycation end products (AGEs) activate mast cells.British journal of pharmacology · 2010Article
- Applications of atomic force microscopy in biophysical chemistry of cells.The journal of physical chemistry. B · 2010Article
- Involvement of the ornithine decarboxylase/polyamine system in precondition-induced cardioprotection through an interaction with PKC in rat hearts.Molecular and cellular biochemistry · 2009Article
- Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion.PloS one · 2009Article
- Impact of actin rearrangement and degranulation on the membrane structure of primary mast cells: a combined atomic force and laser scanning confocal microscopy investigation.Biophysical journal · 2009Article
- Overview of the brain polyamine-stress-response: regulation, development, and modulation by lithium and role in cell survival.Cellular and molecular neurobiology · 2003Review
- Nonmonotonous Changes in Metabolic Parameters of Tissues and Cells under Action of Ionizing Radiation on Animal.Journal of biological physics · 1999Article
- Inhibition of GTPase activity of Gi proteins and decreased agonist affinity at M2 muscarinic acetylcholine receptors by spermine and methoctramine.British journal of pharmacology · 1999Article
- Contractile effects of polycations in permeabilized smooth muscle.Journal of muscle research and cell motility · 1998Article
- "Black holes" and bacterial pathogenicity: a large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Polyamine Binding to Plasma Membrane Vesicles Isolated from Zucchini Hypocotyls.Plant physiology · 1996Article
- Spermine suppresses the activation of human neutrophil NADPH oxidase in cell-free and semi-recombinant systems.The Biochemical journal · 1996Article
- Inhibition of immediate-early-gene induction in renal mesangial cells by depletion of intracellular polyamines.The Biochemical journal · 1994Article
- Cadaverine as a signal of heat shock in plants.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sectionsArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The natural polyamines spermine and spermidine, the biosynthetic precursor putrescine and their analogues cadaverine and tyramine stimulate the GTPase activity of purified GTP-binding proteins (Go/Gi) from calf brain reconstituted into phospholipid vesicles. The order of potency was spermine greater than spermidine greater than putrescine = cadaverine greater than tyramine. The physiological relevance of this observation was assessed, showing the same order of potency of polyamines in the stimulation of peritoneal and tracheal rat mast cells. The activation of rat mast cells by polyamines was inhibited by benzalkonium chloride or by a 2 h pretreatment of the cells with pertussis toxin. The increase in inositol phosphates evoked by polyamines was also inhibited by pertussis toxin. Therefore we propose that intracellular polyamines might control the basal level of second messengers and modulate extracellular signals transduced through G-protein-coupled receptors.
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